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Current Drug Metabolism, 2008
Transcriptomics, a genome-wide measurement of mRNA expression levels based on DNA microarray technology is one of the prominent fields of study. This is the term given to the set of all transcripts or messenger RNA (mRNA) molecules produced in cells. It can also be applied to the specific subset of transcripts present in a particular cell or the total ...
Virendra S, Gomase, Somnath, Tagore
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Transcriptomics, a genome-wide measurement of mRNA expression levels based on DNA microarray technology is one of the prominent fields of study. This is the term given to the set of all transcripts or messenger RNA (mRNA) molecules produced in cells. It can also be applied to the specific subset of transcripts present in a particular cell or the total ...
Virendra S, Gomase, Somnath, Tagore
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Cancer Cell, 2022
Spatial transcriptomics, with other spatial technologies, has enabled scientists to dissect the organization and interaction of different cell types within the tumor microenvironment. We asked experts to discuss some aspects of this technology from revealing the tumor microenvironment and heterogeneity, to tracking tumor evolution, to guiding tumor ...
Ana C, Anderson +12 more
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Spatial transcriptomics, with other spatial technologies, has enabled scientists to dissect the organization and interaction of different cell types within the tumor microenvironment. We asked experts to discuss some aspects of this technology from revealing the tumor microenvironment and heterogeneity, to tracking tumor evolution, to guiding tumor ...
Ana C, Anderson +12 more
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Urologic Oncology: Seminars and Original Investigations, 2020
Improvements in chemistry, molecular biology, genetics, and bioinformatics have allowed broad use of transcriptomic profiling. Understanding the population of ribonucleic acid (RNA) transcripts can provide important clinical information relevant to kidney cancer care.
Jamil Syed +4 more
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Improvements in chemistry, molecular biology, genetics, and bioinformatics have allowed broad use of transcriptomic profiling. Understanding the population of ribonucleic acid (RNA) transcripts can provide important clinical information relevant to kidney cancer care.
Jamil Syed +4 more
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Expansion Spatial Transcriptomics
Nature Methods, 2022AbstractCapture array-based spatial transcriptomics methods have been widely used to resolve gene expression in diverse tissue contexts, however, their spatial resolution is limited by array density. We present Expansion Spatial Transcriptomics (Ex-ST) to overcome this limitation by clearing and expanding tissue prior to capturing the entire ...
Yuhang Fan +8 more
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Nature Reviews Genetics, 2020
A new study in Nature Methods presents the ‘ZipSeq’ spatial transcriptomics approach, whereby patterned illumination is used to print barcodes onto chosen tissue regions.
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A new study in Nature Methods presents the ‘ZipSeq’ spatial transcriptomics approach, whereby patterned illumination is used to print barcodes onto chosen tissue regions.
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Interrogating the transcriptome
Trends in Biotechnology, 2004The human genome sequence and that of several model organisms have provided a remarkable view of the fundamental genetic and evolutionary templates that govern the characteristics of living organisms. Yet the real effectors of phenotype are important downstream informational elements represented first in the transcriptome and then in the proteome. This
Pierre Le Ber +4 more
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2011
Transcriptome analysis technologies are important systems-biology methods for the investigation and optimization of mammalian cell cultures concerning with regard to growth rates and productivity. For the production of recombinant proteins, knowledge of the expression conditions of the influencing genes is a major issue in the improvement of cell lines
Frank, Stahl +7 more
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Transcriptome analysis technologies are important systems-biology methods for the investigation and optimization of mammalian cell cultures concerning with regard to growth rates and productivity. For the production of recombinant proteins, knowledge of the expression conditions of the influencing genes is a major issue in the improvement of cell lines
Frank, Stahl +7 more
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Transcriptomic Analyses of Phytoplasmas
2018Transcriptomic analyses addressed to study phytoplasma gene expression may present few difficulties due to the uncultivable nature of these intracellular, obligate pathogens. While RNA extraction from insect vectors does not imply any particular adaptation of the protocols used in most commercial kits, RNA isolation from phytoplasma-infected plants can
Pacifico D, Abba S, Palmano S
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Transcriptomics on Small Samples
2012Interrogating the cell-specific transcriptome forms an important component of understanding the role that specific cells play in assisting a plant to overcome abiotic stress. Among the challenges arising when extracting RNA from individual plant cells are: the isolation of pure cell populations; the small yield of material when isolating specific cell ...
Roy, S. +4 more
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