IMPORTANCEEvidence from randomized clinical trials of transcutaneous auricular vagus nerve stimulation (taVNS) for chronic insomnia disorder is lacking.OBJECTIVETo evaluate the efficacy and safety of taVNS for chronic insomnia compared with the sham taVNS.DESIGN, SETTING, and PARTICIPANTSThis randomized clinical trial was conducted from October 2021 to
Zhang S +11 more
europepmc +3 more sources
Brain–Heart Interaction During Transcutaneous Auricular Vagus Nerve Stimulation [PDF]
ObjectivesTranscutaneous auricular vagus nerve stimulation (taVNS) modulates brain activity and heart function. The induced parasympathetic predominance leads to an increase of heart rate variability (HRV). Knowledge on the corresponding cortical activation pattern is, however, scarce.
Kathrin Machetanz +3 more
openaire +3 more sources
Auricular transcutaneous vagus nerve stimulation modulates the heart-evoked potential [PDF]
There is active interest in biomarker discovery for transcutaneous auricular vagus nerve stimulation (taVNS). However, greater understanding of the neurobiological mechanisms is needed to identify candidate markers. Accumulating evidence suggests that taVNS influences activity in solitary and parabrachial nuclei, the primary brainstem relays for the ...
Tasha Poppa +7 more
openaire +6 more sources
Neuro-cardiac coupling predicts transcutaneous auricular vagus nerve stimulation effects [PDF]
Transcutaneous auricular Vagus Nerve Stimulation (taVNS) is a non-invasive neuromodulation technique that may constitute an effective treatment for a wide range of neurological, psychiatric, and medical conditions. One key challenge in taVNS research is the high interindividual response variability.
Marius Keute +4 more
openaire +3 more sources
Auricular Transcutaneous Vagus Nerve Stimulation Acutely Modulates Brain Connectivity in Mice [PDF]
Brain electrical stimulation techniques take advantage of the intrinsic plasticity of the nervous system, opening a wide range of therapeutic applications. Vagus nerve stimulation (VNS) is an approved adjuvant for drug-resistant epilepsy and depression.
Cecilia Brambilla-Pisoni +10 more
openaire +4 more sources
Transcutaneous Auricular Vagus Nerve Stimulation Triggers Melatonin Secretion and Is Antidepressive in Zucker Diabetic Fatty Rats [PDF]
Decreased circulating melatonin is implicated in depression. We recently found that Zucker diabetic fatty rats (ZDF, fa/fa) develop depression-like behaviors and that transcutaneous auricular vagus nerve stimulation (taVNS) is antidepressive in ZDF rats.
Ben, Hui +7 more
core +9 more sources
The anatomical basis for transcutaneous auricular vagus nerve stimulation [PDF]
AbstractThe array of end organ innervations of the vagus nerve, coupled with increased basic science evidence, has led to vagus nerve stimulation (VNS) being explored as a management option in a number of clinical disorders, such as heart failure, migraine and inflammatory bowel disease.
Mohsin F. Butt +3 more
openaire +2 more sources
Transcutaneous Auricular Vagus Nerve Stimulation Facilitates Cortical Arousal and Alertness
Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising noninvasive technique with potential beneficial effects on human emotion and cognition, including cortical arousal and alertness. However, it remains unclear how taVNS could improve cortical arousal and alertness, which are crucial for consciousness and daily task performance. Here,
Yuxin Chen, Xuejing Lu, Li Hu
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Transcutaneous vagus nerve stimulation does not affect verbal memory performance in healthy volunteers [PDF]
Introduction: Invasive vagus nerve stimulation (VNS) improves word recognition memory in patients with epilepsy. Recent studies with transcutaneous VNS (tVNS) have also shown positive effects on various subdomains of cognitive functioning in healthy ...
Boon, Paul +8 more
core +1 more source
Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin
Vagus nerve stimulation (VNS) facilitates weight loss in animals and patients treated with VNS for depression or epilepsy. Likewise, chronic transcutaneous auricular VNS (taVNS) reduces weight gain and improves glucose tolerance in Zucker diabetic fatty rats. If these metabolic effects of taVNS observed in rats translate to humans is unknown. Therefore,
Erica M. Kozorosky +5 more
openaire +3 more sources

