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Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: In vivo
Colloids and Surfaces B: Biointerfaces, 2006In vivo transdermal permeation of tetracaine hydrochloride encapsulated in lecithin water-in-oil and oil-in-water microemulsion was studied. The effect of the composition of the lecithin microemulsion on analgesic response of tetracaine hydrochloride was evaluated on Wistar rats by tail flick method.
Jagdish Chander +2 more
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Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids
Cannabis and Cannabinoid ResearchIntroduction: This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. Methods: A systematic and comprehensive literature search across academic databases, search engines, and online sources to identify relevant literature on the
Atefeh Torabi +2 more
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Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships
Current Medicinal Chemistry, 2005Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
Kateřina Vávrová +2 more
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Transdermal permeation enhancement of N-trimethyl chitosan for testosterone
International Journal of Pharmaceutics, 2008The aim of this study was to evaluate the transdermal permeation enhancement of N-trimethyl chitosan (TMC) with different degrees of quaternization (DQ). TMCs with DQ of 40 and 60% (TMC40 and TMC60) were synthesized and characterized by (1)H NMR. Testosterone (TS) used as an effective drug, four different gels were prepared without enhancer, with 5 ...
Wen He, Mian Zhang, Xianxi Guo
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Transdermal delivery of naloxone: ex vivo permeation studies
International Journal of Pharmaceutics, 1999The purpose of this investigation was to study the feasibility of transdermal drug delivery of the potent opioid antagonist naloxone. The pharmacokinetic profile of naloxone makes it a suitable candidate for transdermal delivery. Ex vivo permeation of naloxone through excised rat skin was studied using a diffusion cell.
Ramesh Panchagnula +2 more
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In vitro transdermal permeation and penetration properties for transfersomes of brucine
China Journal of Chinese Materia Medica, 2016To prepare the liposomes and transfersomes of brucine, characterize their pharmaceutical properties, and compare their in vitro transdermal permeation properties. The liposomes and transfersomes of brucine were prepared by ammonium sulfate gradient method to investigate their pharmaceutical properties such as the particle size, encapsulation efficiency
Jun Chen +4 more
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Transdermal Absorption of Radioprotectors Using Permeation-Enhancing Vehicles
Radiation Research, 1990Radioprotectors are not currently used clinically due to concerns regarding toxicity and uncertainties regarding tumor protection. Topical radioprotection of skin might find clinical applications with protectors such as WR-2721, but laboratory studies in which protectors have been applied in water have not been promising. We have studied the absorption
Albert A. Lamperti +2 more
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Transdermal delivery of zalcitabine
AIDS, 1995To study the feasibility of transdermal delivery of anti-HIV drugs in order to maintain blood concentration within the therapeutic range for longer duration and to reduce the side-effects associated with high dose administration.The effects of vehicles and enhancers on the skin permeation rate of zalcitabine (ddC) were investigated to determine the ...
Dae-Duk Kim, Yie W. Chien
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Applications of ultrasonic skin permeation in transdermal drug delivery
Expert Opinion on Drug Delivery, 2008Transdermal ultrasound-mediated drug delivery has been studied as a method for needle-less, non-invasive drug administration. Potential obstacles include the stratum corneum, which is not sufficiently passively permeable to allow effective transfer of many medications into the bloodstream without active methods.
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Chemical Modulation of Topical and Transdermal Permeation [PDF]
, 2019 Marc B. Brown, Adrian C. Williams
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