Results 91 to 100 of about 346,421 (355)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

High-speed mechano-active multielectrode array for investigating rapid stretch effects on cardiac tissue

Nature Communications, 2019
While strain is known to affect cardiac electrophysiology, experimental systems to interrogate the effect of rapid strain cycles on cardiac tissue are lacking.
Matthias Imboden, Etienne de Coulon, Alexandre Poulin, Christian Dellenbach, Samuel Rosset, Herbert Shea, Stephan Rohr   +6 more
doaj   +1 more source

Interdigital Piezopolymer Transducers for Time of Flight Measurements with Ultrasonic Lamb Waves on Carbon-Epoxy Composites under Pure Bending Stress [PDF]

, 2015
Andrea Bulletti, Lorenzo Capineri
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Microscale photoacoustic imaging via laser-induced ultrasound in microfluidic environments

JPhys Photonics
Photoacoustic (PA) imaging offers a powerful non-invasive approach for visualizing optically absorbing structures within biological tissues and microfluidic (MF) devices. While conventional PA imaging often relies on complex inverse problem solutions and
Jonathan U Álvarez-Martínez, R Castro-Beltrán, Gerardo Gutiérrez-Juárez, Gary A Baker, Luis Polo-Parada   +4 more
doaj   +1 more source

Parsing Unranked Tree Languages, Folded Once

Algorithms
A regular unranked tree folding consists of a regular unranked tree language and a folding operation that merges (i.e., folds) selected nodes of a tree to form a graph; the combination is a formal device for representing graph languages.
Martin Berglund, Henrik Björklund, Johanna Björklund   +2 more
doaj   +1 more source

Multiwavelength Single-Longitudinal-Mode Brillouin–Erbium Fiber Laser Sensor for Temperature Measurements With Ultrahigh Resolution

IEEE Photonics Journal, 2015
A multiwavelength single-longitudinal-mode (SLM) Brillouin-erbium fiber laser sensor with ultrahigh resolution is proposed and investigated experimentally. The one short common cavity with 50 m of single mode fiber (SMF) as the fiber under test and 100 m
Yi Liu, Mingjiang Zhang, Peng Wang, Lan Li, Yuncai Wang, Xiaoyi Bao   +5 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

The influence of Pb vacancies on the properties of PZT-type ceramic transducers

Archives of Acoustics, 2000
This article is dedicated to prof. J. Ranachowski The result of investigations of the influence of lead vacancies on the crystalline structure of PZT-type ceramic piezoelectric materials is presented.
Z. SUROWIAK, L. KOZIELSKI, B. WODECKA-DUŚ, E.G. FESENKO, O.N. RAZUMOVSKAYA, L.A. REZNICHENKO, I.N. ZAKHARCHENKO   +6 more
doaj  

Low-Complexity TOAD-Based All-Optical Sampling Gate With Ultralow Switching Energy and High Linearity

IEEE Photonics Journal, 2015
We present experimentally a low-complexity ultralow switching energy and high-linearity all-optical sampling gate based on a terahertz optical asymmetric demultiplexer, constructed by placing a polarization-insensitive multiple-quantum-well semiconductor
P. Li, L. Jiang, J. G. Zhang, J. Z. Zhang, Y. C. Wang   +4 more
doaj   +1 more source