Results 351 to 360 of about 928,471 (414)

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

open access: yesAdvanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang   +8 more
wiley   +1 more source

VCPIP1 facilitates pancreatic adenocarcinoma progression via Hippo/YAP signaling. [PDF]

open access: yesCell Death Dis
Liu Z   +9 more
europepmc   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

open access: yesAdvanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang   +8 more
wiley   +1 more source

A Protoplast System for CRISPR-Cas Ribonucleoprotein Delivery in <i>Pinus taeda</i> and <i>Abies fraseri</i>. [PDF]

open access: yesPlants (Basel)
Marques BM   +9 more
europepmc   +1 more source

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9. [PDF]

open access: yesSci Rep
Palomino SM   +10 more
europepmc   +1 more source

Closing the gap: Nonviral TFAMoplex transfection boosted by bZIP domains compared to AAV-mediated transduction. [PDF]

open access: yesMol Ther Nucleic Acids
Honrath S   +6 more
europepmc   +1 more source

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA. [PDF]

open access: yesNat Commun
Cheng MHY   +16 more
europepmc   +1 more source

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