Results 111 to 120 of about 9,189,722 (330)
Combined Barrier–Target Coverage for Directional Sensor Network
SensorsOver the past twenty years, camera networks have become increasingly popular. In response to various demands imposed on these networks, several coverage models have been developed in the scientific literature, such as area, trap, barrier, and target ...
Balázs Kósa +3 more
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Chlorophylls. VIII. Synthesis of a New Chlorophyll Derivative and Anthraquinone-Based Dyad and Triad Molecules for Executing Photoinduced Electron Transfer. [PDF]
, 1997 Andrei Y. Tauber +9 more
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
OncoImmunologyStratification of the prognosis of pancreatic cancer (PDAC) patients treated by surgery is based solely on clinical variables, such as tumor stage and node status.
Coralie Schoumacher +11 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Cancer cell-derived IL-1β reverses chemo-immunotherapy resistance in non-small cell lung cancer
Nature CommunicationsMany non-small cell lung cancer (NSCLC) patients remain unresponsive to the current standard of care, which includes chemotherapy and immune checkpoint inhibitors, like anti-PD-1/PD-L1 antibodies. While interleukin (IL)-1β is known to promote lung cancer
Anaïs Perrichet +23 more
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Effects of yeast extract and methyl jasmonate on the enhancement of solasodine biosynthesis in cell cultures of Solanum hainanense Hance [PDF]
Journal of BioScience and Biotechnology, 2014 In this work, the effects of the elicitors methyl jasmonate (MeJA) and yeast extract (YE) on the growth and solasodine production of Solanum hainanense cells were investigated. The results showed that various concentrations of MeJA (50-250 µM) and YE (1-4
NGUYEN HOANG LOC +3 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Agricultural Extension in the Pluralistic Ecosystem in India
International Journal of Bio-Resource and Stress Management, 2017 Agricultural extension has played a pivotal role in the agricultural development in India. It is turning new leaf every day, adding new dimension to itself.
Jagriti Rohit +4 more
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