Results 111 to 120 of about 3,573,550 (297)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Recovery from a transfer disruption
, 2014 The present study examined the role of skill acquisition and skill transfer in relation to both Anderson's (1993) Adaptive Control of Thought theory and Logan's (1988) instance theory.
., Craig P. Speelman +1 more
core
Heat transfer during film condensation of a liquid metal vapor [PDF]
, 1964 The object of this investigation is to resolve the discrepancy between theory and experiment for the case of heat transfer durirnfilm condensation of liquid metal vapors.
Sukhatme, S. P., Rohsenow, Warren M.
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Agricultural Extension in the Pluralistic Ecosystem in India
International Journal of Bio-Resource and Stress Management, 2017 Agricultural extension has played a pivotal role in the agricultural development in India. It is turning new leaf every day, adding new dimension to itself.
Jagriti Rohit +4 more
doaj
PhotonicsThe reservoir computing approach based on a semiconductor laser with optoelectronic time-delay feedback is distinguished by its simplicity, speed, and reliability.
Anton Kovalev +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The mechanism of heat transfer in nucleate pool boiling [PDF]
, 1962 A criterion is developed for bubble initiation from a gas filled cavity on a surface in contact with a superheated layer of liquid. It is found that the temperature of bubble initiation on a given surface is a function of the temperature conditions in ...
Han, Chi-Yeh, Griffith, P.
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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