Results 101 to 110 of about 4,170,262 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Motional effects on the efficiency of excitation transfer

, 2010
Energy transfer plays a vital role in many natural and technological processes. In this work, we study the effects of mechanical motion on the excitation transfer through a chain of interacting molecules with application to biological scenarios of ...
Ali Asadian, Cai J Popescu S Briegel H J, Caruso F Chin A W Datta A Huelga S F Plenio M B, Chin A W Datta A Caruso F Huelga S F Plenio M B, Davydov A S, Förster T, Gian Giacomo Guerreschi, Hans J Briegel, Jianming Cai, Markus Tiersch, Panitchayangkoon G Hayes D Fransted K A Caram J R Harel E Wen J Blankenship R E Engel G S, Perrin F, Plenio M B, Sandu Popescu, Scholak T de Melo F Wellens T Mintert F Buchleitner A, Semião F L Furuya K Milburn G J   +15 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Effects of Foreign Direct Investments for Host Country’s Economy [PDF]

European Journal of Interdisciplinary Studies, 2013
Foreign Direct Investment (FDI) is seen as the fundamental part for an open and successful international economic system and a major mechanism for development. In this circumstance, the paper examines the benefits of FDI as a key component for successful
Selma KURTISHI-KASTRATI
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring Working Memory Capacity and Efficiency Processes to Understand Working Memory Training Outcomes in Primary School Children

Journal of Cognition
Despite the abundance of research evaluating working memory training outcomes in children, few studies have examined the underlying cognitive mechanisms.
Alexandra S. L. Tan, Regine C. Lau, Peter J. Anderson, Susan Gathercole, Mark A. Bellgrove, Joshua F. Wiley, Megan M. Spencer-Smith   +6 more
doaj   +1 more source

Off-Court Generic Perceptual-Cognitive Training in Elite Volleyball Athletes: Task-Specific Effects and Levels of Transfer

Frontiers in Psychology, 2019
Background: The nature of perceptual-cognitive expertise in interactive sports has gained more and more scientific interest over the last two decades. Research to understand how this expertise can be developed has not been addressed profoundly yet.
Marie-Therese Fleddermann, Holger Heppe, Holger Heppe, Karen Zentgraf   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Transboundary Pollution and Welfare Effects of Technology Transfer [PDF]

The purpose of this paper is to examine the welfare effects of pollution abatement technology transfer in a two-good two-country model with transboundary pollution. In each country, one industry emits pollution as a joint product of output and the sum of
Yasuhiro Takarada
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source