Results 71 to 80 of about 2,532,270 (350)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Evaluation of Transfer Efficiency between Subway and Bus Based on the Interval Number Ranking Method by Employing Probability Reliability: Taking Ningbo for Example

Discrete Dynamics in Nature and Society, 2021
In recent years, the construction and operation of urban subways have been gradually increasing in developing countries. In the next step, more attention should be paid to the transfer efficiency between subway and bus so as to improve the travel ...
Zhenyu Chen, Zhengfeng Huang, Lingli Yang, Pengjun Zheng   +3 more
doaj   +1 more source

Numerical study on heat transfer efficiency for borehole heat exchangers in Linqu County, Shandong Province, China

Energy Reports, 2022
Developing shallow geothermal energy with borehole heat exchangers helps energy supply and CO2 emission reduction. This paper comprehensively investigates the influencing factors on heat transfer efficiency of a single borehole heat exchanger based on ...
Zongjun Gao, Ziyuan Hu, Tao Chen, Xiqiang Xu, Jianguo Feng, Yongshuai Zhang, Qiao Su, Deshuai Ji   +7 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Decaying cyclonic eddies enhance deep carbon transfer while frontal zones attenuate export: mechanistic drivers of divergent pathways

Environmental Research Letters
Ubiquitous mesoscale eddy-front systems are hotspots of carbon export, yet how their decay phase regulates the biological pump in strongly stratified oceans remains unknown. Utilizing ship-based observations from a decaying cyclonic eddy off southeastern
Xinyang Wang, Jingjing Zhang, Hongliang Li, Shuh-Ji Kao, Jie Xu, Feng Zhou, Jiliang Xuan, Ruibin Ding, Lu Shou, Yuanli Zhu, W N C Priyadarshani, Jianfang Chen   +11 more
doaj   +1 more source

A Three-Coil Inductively Power Transfer System with Constant Voltage Output

Energies, 2018
For a traditional 2-coil system outputting constant voltage (CV), the transfer efficiency decreases drastically as transfer distance increases. To solve this problem, this essay proposes a 3-coil system which could achieve CV output and Zero Phase Angle (
Ruikun Mai, Youyuan Zhang, Ruimin Dai, Yang Chen, Zhengyou He   +4 more
doaj   +1 more source

A Maximum Transfer Efficiency Tracking Method for Dynamic Wireless Charging Systems of Electric Vehicles

Journal of Electrical and Computer Engineering, 2021
This paper proposes a new control method to improve transfer efficiency for dynamic wireless charging systems of electric vehicles (EVs). In the charging process, the equivalent impedance in the receiving side varies according to the state of charge of ...
Nguyen Kien Trung, Nguyen Thi Diep
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source