Results 71 to 80 of about 315,169 (276)
Driving force of water entry into hydrophobic channels of carbon nanotubes: entropy or energy?
, 2015 Spontaneous entry of water molecules inside single-wall carbon nanotubes (SWCNTs) has been confirmed by both simulations and experiments. Using molecular dynamics simulations, we have studied the thermodynamics of filling of a (6,6) carbon nanotube in a ...
Dasgupta, Chandan +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Case Studies in Thermal Engineering, 2017 In the present study, calculations of the heat transfer and entropy generation have been performed for the steady state forced convection heat transfer in shell and helically coiled tube heat exchangers.
Ashkan Alimoradi, Farzad Veysi
doaj +1 more source
Thermodynamic efficiency of information and heat flow
, 2009 A basic task of information processing is information transfer (flow). Here we study a pair of Brownian particles each coupled to a thermal bath at temperature $T_1$ and $T_2$, respectively.
+25 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Granger causality and transfer entropy are equivalent for Gaussian variables
, 2009 Granger causality is a statistical notion of causal influence based on prediction via vector autoregression. Developed originally in the field of econometrics, it has since found application in a broader arena, particularly in neuroscience. More recently
A. Papoulis +11 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Inferring causal relationships in zebrafish-robot interactions through transfer entropy: a small lure to catch a big fish [PDF]
Animal Behavior and Cognition, 2018 In the field of animal behavior, effective methods to apprehend causal relationships that underlie the interactions between animals are in dire need. How to identify a leader in a group of social animals or quantify the mutual response of predator and ...
Maurizio Porfiri
doaj +1 more source
A unified framework for information integration based on information geometry
, 2015 We propose a unified theoretical framework for quantifying spatio-temporal interactions in a stochastic dynamical system based on information geometry.
Amari, Shun-ichi +2 more
core +1 more source