Results 71 to 80 of about 317,661 (275)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Entropy and Its Correlations with Other Related Quantities
Entropy, 2014 In order to find more correlations between entropy and other related quantities, an analogical analysis is conducted between thermal science and other branches of physics. Potential energy in various forms is the product of a conserved extensive quantity
Jing Wu, Zengyuan Guo
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Case Studies in Thermal Engineering, 2017 In the present study, calculations of the heat transfer and entropy generation have been performed for the steady state forced convection heat transfer in shell and helically coiled tube heat exchangers.
Ashkan Alimoradi, Farzad Veysi
doaj +1 more source
Specific transfer entropy and other state-dependent transfer entropies for continuous-state input-output systems [PDF]
Physical Review E, 2017 Since its original formulation in 2000, transfer entropy has become an invaluable tool in the toolbox of nonlinear dynamicists working with empirical data. Transfer entropy and its generalizations provide a precise definition of uncertainty and information transfer that are central to the coupled systems studied in nonlinear science.
David, Darmon, Paul E, Rapp
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
General form of entropy on the horizon of the universe in entropic cosmology
, 2016 Entropic cosmology assumes several forms of entropy on the horizon of the universe, where the entropy can be considered to behave as if it were related to the exchange (the transfer) of energy.
Kimura, Shigeo, Komatsu, Nobuyoshi
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Entropy, 2018 The heat and matter transfer during glucose catabolism in living systems and their relation with entropy production are a challenging subject of the classical thermodynamics applied to biology.
Roberto Zivieri, Nicola Pacini
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source