Results 71 to 80 of about 2,176,446 (301)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Beta-Amino Phosphine Mn Catalysts for 1,4-Transfer Hydrogenation of Chalcones and Allylic Alcohol Isomerization [PDF]

, 2019
Beta-amino phosphines derived from amino-acids are excellent supporting ligands for Mn(I) transfer hydrogenation catalysts. Namely, a variety of ketones and chalcones are efficiently reduced under mild conditions (2-propanol, 3 h, 60 °C).
David, Lacy, Vipulan Vigneswaran (7165974), Vipulan, Vigneswaran, David Lacy (6330638)   +3 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Synthesis and characterization of ruthenium compounds incorporating keto-amine ligands. The applications of catalytic transfer hydrogenation and cancer cell inhibition

, 2017
A series of keto-amine bidentate precursors 1-5, OCCH3CHCCH3NHR (where 1, R = C6H3-2,6-Pr-i(2); 2, R = C6H2-2,4,6-Me-3; 3, R = C6H4-2-Bu-t; 4, R = C6H4-2-OMe; 5, R = C6H4-2-OMe-5-Me) were synthesized and combined with [Ru(eta(6)-p-cymene)Cl-2](2) to ...
顧記華, Lin, Tzung-Han;Das, Kuheli;Datta, Amitabha;Leu, Wohn-Jenn;Hsiao, Hung-Chang;Lin, Chia-Her;Guh, Jih-Hwa;Huang, Jui-Hsien   +1 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hydrogen donors in catalytic transfer hydrogenation: structure-reactivity relationships and mechanistic perspectives

Tetrahedron Chem
Catalytic transfer hydrogenation (CTH) has emerged as a powerful and versatile alternative to high-pressure hydrogenation, providing enhanced safety, operational simplicity, and broad functional-group compatibility.
Gazal Sabharwal, Khilesh C. Dwivedi, Maravanji S. Balakrishna   +2 more
doaj   +1 more source

Asymmetric Hydrogen Atom Transfer

ACS Catalysis
Achieving high enantioselectivity in radical reactions has been a long-standing challenge in synthetic organic chemistry. Given the ubiquity of HAT events in radical reactions, strategies for achieving asymmetric HAT have significant synthetic potential as manifested by the recent surge of reports involving enantioselective HAT. In this Perspective, we
Andrew G. Feng, Marcus Vinicius Pinto Pereira Junior, Scott J. Miller, Robert R. Knowles   +3 more
openaire   +2 more sources

Model arenes hydrogenation with silica-supported rhodium nanoparticles:The role of the silica grains and of the solvent on catalytic activities [PDF]

, 2009
Silica-supported rhodium-based nanoheterogeneous catalysts were easily prepared by impregnation with a pre-stabilized colloidal suspension. The resulting catalysts contain rhodium nanoparticles well-dispersed in the silica pores with a mean size of 5 nm.
Philippot, Karine, Hemati, Mehrdji, Chaudret, Bruno, Denicourt-Nowicki, A., Roucoux, Alain, Denicourt-Nowicki, Audrey, Barthe, Laurie   +6 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source