Results 91 to 100 of about 511,651 (264)

Entropia de cadeias dispostas numa rede unidimensional

open access: yesRevista Brasileira de Ensino de Física
Com frequência, cálculos das propriedades termodinâmicas em modelos mecânico-estatísticos envolvem problemas de contagem bastante complexos. Um caso deste tipo, que tem sido estudado há bastante tempo, é o do cálculo do número de maneiras de inscrever ...
Jürgen F. Stilck, Wellington G. Dantas
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Study on land use change of Dajiu lake and its impact on ecological environment in the last 60 years

open access: yesCarsologica Sinica
Dajiu lake of Shennongjia is a typical, unique and rare subalpine peat-swamp wetland in China. From 1985 to 2002, due to the building of farms, the area of Dajiu lake had been transformed from wetlands to farmlands, for example, transforming natural ...
Xiaojun MENG   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Investigation of Longitudinal Vibration of Flexible Ultrasonic Waveguides by Means of Transfer-Matrix Method

open access: yesМеханика машин, механизмов и материалов, 2011
The article considers application of the transfer-matrix method for calculating resonant frequencies of longitudinal vibration of flexible ultrasonic waveguides.
D.A. Stepanenko   +2 more
doaj  

A Simulation‐Based Study of a Black Phosphorus‐Based Complex Multilayer SPR‐Based Optical Sensor for Wastewater Monitoring

open access: yesElectron
The increasing global threat of water pollution demands advanced multilayer sensing technologies with efficacy to detect contaminants with high sensitivity and adaptability in complex aquatic environments.
Vishal Chaudhary   +3 more
doaj   +1 more source

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