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Evolution of transfer RNA

Journal of Molecular Biology, 1973
Abstract Evolution by gene duplication and subsequent divergence is indicated by similarities common to 43 different transfer RNAs. Pairwise comparisons of these tRNAs reveal additional similarity, greatest for certain pairs of tRNAs for the same amino acid in the same organism, and also occurring in certain pairs of tRNAs for different amino acids ...
R, Holmquist, T H, Jukes, S, Pangburn
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Transfer RNA Modification

EcoSal Plus, 2005
Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica contains 31 different modified nucleosides, which are all, except for one (Queuosine[Q]), synthesized on an oligonucleotide ...
Glenn R, Björk, Tord G, Hagervall
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Transfer RNAs and transfer RNA-derived small RNAs in cerebrovascular diseases

Experimental Neurology
This article explores the important functions of transfer RNA and - transfer RNA derived small RNAs (tsRNAs) in cellular processes and disease pathogenesis, with a particular emphasis on their involvement in cerebrovascular disorders. It discusses the biogenesis and structure of tsRNAs, including types such as tRNA halves and tRNA-derived fragments ...
Jiajie, Yuan   +14 more
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Transfer RNA in Hepatomas

1978
1. Altered column-chromatographic profiles of a number of hepatoma and other tumor aminoacyl-tRNAs have been observed, most frequently for tRNAPhe, tRNAAsp, tRNAAsn, tRNATyr, tRNAHis, and tRNASer. 2. The chemical basis for the chromatographic alterations is still obscure, except that a tRNAPhe in Morris hepatoma 7777, which is not ...
E, Randerath   +2 more
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Transfer RNA nucleotidyltransferase repairs all transfer RNAs randomly

Journal of Molecular Biology, 1977
Total Escherichia coli transfer RNA was converted to tRNA-C-C by periodate oxidation and partially repaired with either E. coli or rabbit liver tRNA nucleotidyltransferase. Aminoacylation of the partially repaired molecules indicated that individual tRNA species were each repaired to the same extent as the total population of molecules.
M P, Deutscher, J A, Evans
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Mitochondrial transfer RNAs in yeast: identification of isoaccepting transfer RNAs

Biochemistry, 1978
To delineate the total number of tRNAs encoded by yeast mitochondrial DNA (mtDNA), we have examined mitochondrial tRNA preparations for the presence of heterogenic isoaccepting tRNAs. Analyses of /sup 3/H-labeled aminoacylated mitochondrial tRNAs by reversed-phase column chromatography (RPC-5) coupled with hybridization to mtDNA detected only one major
N C, Martin, M, rabinowitz
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Transfer RNA in RNA Tumor Viruses

1977
Publisher Summary This chapter reviews that the presence of the majority of the tRNAs inside an RNA tumor virus remains an enigma. The finding that specific tRNA molecules can serve as primers for DNA synthesis is of fundamental importance in the field of molecular biology.
L C, Waters, B C, Mullin
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Effect of Spermine on Transfer RNA and Transfer RNA-Ribosome Interactions

1988
Translation of genetic message requires a coordianted interplay of more than a hundred kinds of macromolecules. Besides the ribosomes, which are multicomponent ribonucleoprotein particles by their own nature, molecules of transfer RNA, aminoacyl-tRNA synthetases, soluble protein factors and mRNA are involved in the process.
Z, Kućan   +4 more
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GENETICS OF TRANSFER RNA

Annual Review of Genetics, 1972
Initially the only way of identifying tRNA genes was by DNA-RNA hy­ bridization. The discovery that informational suppression may result from muta­ tions in tRNA genes has not only allowed their genetic analysis but has led to the isolation of mutants important in understanding the function, structure, and synthesis of tRNA.
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Transfer RNA nucleotidyltransferase

1990
Publisher Summary All tRNA molecules contain, at the 3′ terminus, the identical-CCA sequence that is required for their acceptor and transfer functions. In prokaryotic cells, no discrete pattern has emerged. In laboratory strains of Escherichia coli , all tRNA genes sequenced encode the -CCA sequence, and mutant strains devoid of tRNA ...
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