Results 241 to 250 of about 155,620 (276)

Profile analysis reveals transfer RNA fragments involved in mesangial cells proliferation

Biochemical and Biophysical Research Communications, 2019
Mesangial cell (MCs) proliferation is an essential component of glomerulonephritis. To find some bio-markers of mesangial cell proliferation, we investigate the relationship between transfer RNA fragments (tRFs) and proliferating mesangial cells. The model of proliferating mesangial cells was built by using transforming growth factor-1(TGF-β1) treated ...
Xiaoyu, Lu, Xianyi, Zhu, Minyi, Yu, Chen, Na, Weihua, Gan, Aiqing, Zhang   +5 more
openaire   +2 more sources

Partial degradation of transfer RNAs and transfer RNA fragments by spleen phosphodiesterase as studied by disc electrophoretic methods

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
Abstract Disc electrophoretic methods for the separation of tRNAs, tRNA fragments and oligonucleotides on the analytical and preparative scale were modified and improved. In the analytical separations the components were quantitatively determined. Calibration curves relating mobility to chain length permitted the assignment of chain length to unknown
P, Philippsen, G, Zachau
openaire   +2 more sources

Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA

Journal of Molecular Biology, 1974
Abstract Binding of Mn2+ to the whole molecule, fragments and complementary fragment recombinations of yeast tRNAPhe, and to synthetic polynucleotides was studied by equilibrium dialysis. The comparison of the binding patterns of the fragments, fragment recombinations and synthetic polynucleotides with that of intact tRNAPhe permits reasonable ...
A A, Schreier, P R, Schimmel
openaire   +2 more sources

Discovery and function of transfer RNA‐derived fragments and their role in disease

WIREs RNA, 2017
Until recently, transfer RNAs (tRNAs) were thought to function in protein translation only. However, recent findings demonstrate that both pre‐ and mature tRNAs can undergo endonucleolytic cleavage by different ribonucleases originating different types of small non‐coding RNAs, known as tRNA‐derived fragments (tRFs).
Soares, Ana Raquel, Santos, Manuel
openaire   +3 more sources

Ribosomal protein L24 modulates mammalian microRNA processing and transfer RNA fragment production

2023
AbstractThe evolutionary mechanism(s) underlying the expression of novel microRNAs (miRs) are still elusive. To explore this issue, we studied the expression of intronic primate-specific hsa-miR-608, located in the Semaphorin 4G (SEMA4G) gene. Engineered ‘humanized’ mice carrying human miR-608 flanked by 250 bp in the murine Sema4g gene expressed miR ...
Yonat Tzur, Serafima Dubnov, Nimrod Madrer, Adi Bar, Bettina Nadorp, Nibha Mishra, Paul Heppenstall, Estelle R Bennett, David S Greenberg, Katarzyna Winek, Hermona Soreq   +10 more
openaire   +1 more source

A Comprehensive Repertoire of Transfer RNA-Derived Fragments and Their Regulatory Networks in Colorectal Cancer

Journal of Computational Biology, 2020
To provide systematic insight into the composition and expression of transfer RNA (tRNA) derivatives transcriptome in colorectal cancer (CRC). tRNA derivatives expression profiles in three pairs of CRC and adjacent normal colon tissues were performed by tRNA-derived small RNA fragments (tRFs) and tRNA halves (tiRNA) sequencing, and microarray data of ...
Xiaojie, Wang, Yiyi, Zhang, Waleed M, Ghareeb, Shuangming, Lin, Xingrong, Lu, Ying, Huang, Shenghui, Huang, Zongbin, Xu, Pan, Chi   +8 more
openaire   +2 more sources

Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA

Journal of Molecular Biology, 1975
Abstract Binding of the polyamines spermidine (∼-+3) and spermine (∼-+4) to yeast tRNA phe has been investigated by equilibrium dialysis under the same conditions used to study Mn 2+ -tRNA phe interactions (Schreier & Schimmel, 1974). The polyamines bind to tRNA phe in a co-operative and a non-co-operative phase, which is analogous to the behavior
A A, Schreier, P R, Schimmel
openaire   +2 more sources

Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases

Journal of Molecular Medicine, 2018
The number of studies on non-coding RNAs has increased substantially in recent years owing to their importance in gene regulation. However, the biological functions of small RNAs from abundant species of housekeeping non-coding RNAs (rRNA, tRNA, etc.) remain a highly studied topic.
Yijing Shen, Xiuchong Yu, Linwen Zhu, Tianwen Li, Zhilong Yan, Junming Guo   +5 more
openaire   +2 more sources

Transfer RNA Fragments, from Structure to Function

2023
Serafima Dubnov, Hermona Soreq
openaire   +1 more source

Circulating Exosomal Transfer RNA-Related Fragments as Diagnostic Biomarkers for Non-small Cell Lung Cancer

Current Medicinal Chemistry
Aim: Exosomal transfer RNA-derived fragments (exo-tRF) possess the capacity to be employed as biomarkers for several types of cancer. We aim to ascertain the diagnostic significance of exosomal 5’tRF-TyrGTA and 5’tRF-ValTAC in non-small cell lung cancer (NSCLC).
Li, Meng, Zhaolong, Ma, Yingying, Ji, Guangyao, Li, Shiwen, Wang, Zhijun, Zhang   +5 more
openaire   +2 more sources