Results 271 to 280 of about 404,236 (314)

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

From liquid-phase synthesis to chemical ligation: preparation of oligonucleotides and their backbone analogs in solution. [PDF]

Nucleic Acids Res
Virta P.
europepmc   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source

Complete mitochondrial genome of Polygonatum cyrtonema Hua reveals variation diversity and evolutionary trends. [PDF]

BMC Plant Biol
Luo H, Ren F, Cao G, Wang D, Jia Q.
europepmc   +1 more source

Complete Mitochondrial Genomes of Two Water Mite Species in the Family Sperchontidae (Acari: Hydrachnidiae): Characterization and Phylogenetic Implications. [PDF]

Genes (Basel)
Zhang X, Nie X, Xia X, Song J, Wen Q, Sun K.   +5 more
europepmc   +1 more source

Posttranscriptional 3'-Terminal Modifications of <i>Escherichia coli</i> RNA Fragments Evolved for Diversity Boosting. [PDF]

Microorganisms
Kamoldinov NM, Panyukov VV, Kolzhetsov NP, Markelova NY, Shavkunov KS, Shvyreva US, Alikina OV, Glazunova OA, Praslova IA, Ozoline ON.   +9 more
europepmc   +1 more source

Assembly and Comparative Analysis of the Complete Mitochondrial Genome of <i>Bromus inermis</i>. [PDF]

Genes (Basel)
Feng S, Wu Z, Tian C, Yang Y, Gong W, Li Z.   +5 more
europepmc   +1 more source

Recommendations for Validating Omics Prediction Models: Insights from a Lung Cancer RNA Biomarker Study. [PDF]

Cancer Epidemiol Biomarkers Prev
Pestarino L, Fortner RT, Nøst TH, Fotopoulos I, Urbarova I, Røe OD, Langseth H, Rounge TB.   +7 more
europepmc   +1 more source