Results 281 to 290 of about 305,705 (319)

Recovery of transfer RNA functions by combining fragmented Escherichia coli formylmethionine transfer RNA

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
Abstract 1. Limited digestion of Escherichia coli tRNAfMet by ribonuclease T1 resulted mainly in a split at -G-D(dihydrouridine)-sequence in the D loop of the tRNA. The resulting 5′- and 3′-half molecules restored the methionine-acceptor activity and the transformylation ability only when mixed. No activities were recovered with either half alone. It
T, Seno, M, Kobayashi, S, Nishimura
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Transfer RNA‐derived fragments as potential exosome tRNA‐derived fragment biomarkers for osteoporosis

International Journal of Rheumatic Diseases, 2018
AbstractAimOsteoporosis is one of the common orthopedic diseases featured in low bone mineral density. Exosomes have been proven to be potential markers for many diseases and health problems. The roles of messenger RNAs and microRNAs in osteoporosis have been comprehensively studied; however, little research has focused on the function of plasma ...
Yan Zhang, Feng Cai, Ju Liu, Hongze Chang, Liang Liu, Anli Yang, Xiaodong Liu   +6 more
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Infrared Spectrum of an Anticodon Fragment of a Transfer RNA

Nature, 1969
WE have observed the infrared spectrum of a fragment of a transfer RNA (tRNA) in aqueous solution and obtained evidence for the existence of the hydrogen-bonded base pairs.
K, Morikawa, M, Tsuboi, Y, Kyogoku, T, Seno, S, Nishimura   +4 more
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Profile analysis reveals transfer RNA fragments involved in mesangial cells proliferation

Biochemical and Biophysical Research Communications, 2019
Mesangial cell (MCs) proliferation is an essential component of glomerulonephritis. To find some bio-markers of mesangial cell proliferation, we investigate the relationship between transfer RNA fragments (tRFs) and proliferating mesangial cells. The model of proliferating mesangial cells was built by using transforming growth factor-1(TGF-β1) treated ...
Xiaoyu, Lu, Xianyi, Zhu, Minyi, Yu, Chen, Na, Weihua, Gan, Aiqing, Zhang   +5 more
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Partial degradation of transfer RNAs and transfer RNA fragments by spleen phosphodiesterase as studied by disc electrophoretic methods

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
Abstract Disc electrophoretic methods for the separation of tRNAs, tRNA fragments and oligonucleotides on the analytical and preparative scale were modified and improved. In the analytical separations the components were quantitatively determined. Calibration curves relating mobility to chain length permitted the assignment of chain length to unknown
P, Philippsen, G, Zachau
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Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA

Journal of Molecular Biology, 1974
Abstract Binding of Mn2+ to the whole molecule, fragments and complementary fragment recombinations of yeast tRNAPhe, and to synthetic polynucleotides was studied by equilibrium dialysis. The comparison of the binding patterns of the fragments, fragment recombinations and synthetic polynucleotides with that of intact tRNAPhe permits reasonable ...
A A, Schreier, P R, Schimmel
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Discovery and function of transfer RNA‐derived fragments and their role in disease

WIREs RNA, 2017
Until recently, transfer RNAs (tRNAs) were thought to function in protein translation only. However, recent findings demonstrate that both pre‐ and mature tRNAs can undergo endonucleolytic cleavage by different ribonucleases originating different types of small non‐coding RNAs, known as tRNA‐derived fragments (tRFs).
Soares, Ana Raquel, Santos, Manuel
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Ribosomal protein L24 modulates mammalian microRNA processing and transfer RNA fragment production

2023
AbstractThe evolutionary mechanism(s) underlying the expression of novel microRNAs (miRs) are still elusive. To explore this issue, we studied the expression of intronic primate-specific hsa-miR-608, located in the Semaphorin 4G (SEMA4G) gene. Engineered ‘humanized’ mice carrying human miR-608 flanked by 250 bp in the murine Sema4g gene expressed miR ...
Yonat Tzur, Serafima Dubnov, Nimrod Madrer, Adi Bar, Bettina Nadorp, Nibha Mishra, Paul Heppenstall, Estelle R Bennett, David S Greenberg, Katarzyna Winek, Hermona Soreq   +10 more
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A Comprehensive Repertoire of Transfer RNA-Derived Fragments and Their Regulatory Networks in Colorectal Cancer

Journal of Computational Biology, 2020
To provide systematic insight into the composition and expression of transfer RNA (tRNA) derivatives transcriptome in colorectal cancer (CRC). tRNA derivatives expression profiles in three pairs of CRC and adjacent normal colon tissues were performed by tRNA-derived small RNA fragments (tRFs) and tRNA halves (tiRNA) sequencing, and microarray data of ...
Xiaojie, Wang, Yiyi, Zhang, Waleed M, Ghareeb, Shuangming, Lin, Xingrong, Lu, Ying, Huang, Shenghui, Huang, Zongbin, Xu, Pan, Chi   +8 more
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Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA

Journal of Molecular Biology, 1975
Abstract Binding of the polyamines spermidine (∼-+3) and spermine (∼-+4) to yeast tRNA phe has been investigated by equilibrium dialysis under the same conditions used to study Mn 2+ -tRNA phe interactions (Schreier & Schimmel, 1974). The polyamines bind to tRNA phe in a co-operative and a non-co-operative phase, which is analogous to the behavior
A A, Schreier, P R, Schimmel
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