Results 51 to 60 of about 24,890 (264)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

El sujeto nulo español para aprendientes anglófonos: tratamiento en manuales de ELE y reflexiones didácticas [PDF]

marcoELE. Revista de Didáctica Español Lengua Extranjera, 2019
El presente artículo pretende revisar el uso de los sujetos tácitos en la interlengua de los anglófonos aprendientes de español. Esto es de especial interés puesto que parten de una lengua en la que el parámetro del sujeto nulo está desactivado y ...
Jiménez-Fernández, Ángel L., Gómez Marzo, Lucía   +1 more
doaj  

Trust the Process: A New Scientific Outlook on Psychodramatic Spontaneity Training

Frontiers in Psychology, 2018
Human mind is hypothesis-driven and our observations of the world are strongly shaped by preconceptions. This “top-down” principle is biologically driven and contraindicative to spontaneity, which is non-linear, condensed, and initially incomprehensible.
Dani Yaniv
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Source Language and Culture Interference in Translation

ACROSS, 2023
The translation is a process that goes beyond linguistic transformations and demands cross-cultural awareness. However, mistakes resulting from apparently similar linguistic structures in the source and target language as well as narrow cultural views ...
Irina PUȘNEI, Dr.
doaj  

General approach to the sensitivity of the optics of an eye to change in elementary parameters with application to the Gaussian optics of a reduced eye

African Vision and Eye Health, 2009
Optical properties of the eye, including the refractive compensation, for example, may change if there are changes in any of the components that make up the eye.  The sensitivity to such changes isquantified via the derivative.
W. F. Harris
doaj   +1 more source