Results 101 to 110 of about 1,263,349 (289)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
AmerikaThe Río Blanco factory in Veracruz and the La Soledad Vista Hermosa factory, located in the municipality of San Agustín Etla, Oaxaca, were part of a project to modernise the textile industry in Mexico in the late 19th and early 20th centuries.
Mariana Alcántara Lozano
doaj +1 more source
Motives for Household Private Transfers in Burkina Faso [PDF]
Resource transfers among households have received considerable interest among economists in recent years. Two of the main reasons for the surge of interest in household transfers are the information on human nature conveyed by transfer behavior and the ...
Harounan Kaziango
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Revista de Economía y Estadística, 2018 This paper examines the determinants of reelection of parties and mayors in Argentine local elections during the 1983-2011 period. Using a unique and comprehensive database recording local elecion results for over 1200 local governments, we test three ...
Sebastián Freille, Víctor Mazzalay
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Del límite de la urbanización al límite de lo urbano: la construcción territorial del gran París y el gran Madrid (1910-1939) [PDF]
Ciudades, 2016 Town planning practice and discourses experienced a parallel evolution in Madrid and Paris during the first decades of 20th Century. International models and tools were adapted to the local context and to the new challenges of the greater city.
Beatriz Fernández Águeda
doaj