Results 271 to 280 of about 4,175,172 (359)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

What does life-table analysis of sequential euploid blastocyst transfers tell us about recurrent implantation failure-or lack thereof? [PDF]

F S Rep
Paulson RJ.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Efficiency and equity of water transfers to megacities: reconfiguring urban water security in Istanbul. [PDF]

PeerJ
Varty Bayar F, Daloğlu Çetinkaya İ.
europepmc   +1 more source

Americans favor predistributive over redistributive economic policies. [PDF]

Proc Natl Acad Sci U S A
Broska D, Kamphorst J, Willer R.
europepmc   +1 more source

The Fate of Horizontally Acquired Genes: Rapid Initial Turnover Followed by Long-Term Persistence. [PDF]

Mol Biol Evol
Mishra S, Weit K, Lercher MJ.
europepmc   +1 more source

Outcomes From Radial Fascicular Nerve Transfers Including Extensor Carpi Radialis Longus to Triceps for Elbow Extension. [PDF]

Microsurgery
Bhindi N, Ferris S.
europepmc   +1 more source