Results 61 to 70 of about 235,831 (265)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transform Domain Morphological Filters

, 2023
In this thesis, we have studied the concept of mathematical morphologyand morphological operators to devise new methods to recognise andreassemble paths and patterns through point-clouds. These are methodswhich act on the local or global shape-related properties of thecomponents of an $n$-dimensional data set. These methods have beenapplied to the data
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

CDTrans: Cross-domain Transformer for Unsupervised Domain Adaptation

, 2021
Unsupervised domain adaptation (UDA) aims to transfer knowledge learned from a labeled source domain to a different unlabeled target domain. Most existing UDA methods focus on learning domain-invariant feature representation, either from the domain level or category level, using convolution neural networks (CNNs)-based frameworks.
Xu, Tongkun, Chen, Weihua, Wang, Pichao, Wang, Fan, Li, Hao, Jin, Rong   +5 more
openaire   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A Hybrid Clustering Strategy for Transform Domain Communication System

IEEE Access, 2019
In recent years, the various Internet of Things (IoT) communication technologies have been researched. The third generation partnership project (3GPP) is dedicated to building the IoT platforms, including NB-IoT, eMTC, and URLLC. However, these platforms
Shiyong Ma, Su Hu, Xuezhang Zhu, Qiudi Tang, Qu Luo, Yunfeng Zhou   +5 more
doaj   +1 more source

Seam carving in wavelet transform domain

2011 18th IEEE International Conference on Image Processing, 2011
Content aware image resizing technique has become more important with the development of device technology. Although the seam carving method produces high-quality resized images, it requires high computational complexity. In this paper, we propose a faster content-aware image resizing technique.
Kazu Mishiba, Masaaki Ikehara
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dual Watermarking of Medical Images with Private Patient Information Based on Contourlet Transform

مجله دانشکده پزشکی اصفهان, 2012
Background: Advances in information and communication technologies and quick growth in using the Internet on one hand, and changing of medical equipment from analog to digital as well as modified appearance of modern healthcare system, on the other ...
Farhad Rahimi, Hossein Rabbani, Saeed Kermani   +2 more
doaj  

Implementation of wavelet transform based on switched current circuits

Dianzi Jishu Yingyong, 2018
In order to meet the engineering application requirement for low-power and real-time signal processing, an implementation of wavelet transform using switched current(SI) technique is presented in this paper.
Hu Qinchun, Huo Ping, You Xiaoquan, Zhang Song, Guo Lifang, Tan Huayong   +5 more
doaj   +1 more source