Results 71 to 80 of about 235,831 (265)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Efficient Learning of Transform-Domain LMS Filter Using Graph Laplacian. [PDF]

IEEE Trans Neural Netw Learn Syst, 2023
Batabyal T, Weller D, Kapur J, Acton ST.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Wavefield separation using the f–ξ domain for vertical seismic profiling data [PDF]

MATEC Web of Conferences
Wavefield separation is an essential and critical step in data processing of vertical seismic profiles (VSPs). The τ–p transform is one of the effective approaches for separating the VSP wavefield.
Liu Baotong, Liu Qiyuan, Jiang Yingshuang, Liu Donglin, Kang Xuefu   +4 more
doaj   +1 more source

Speed Up of Volumetric Non-Local Transform-Domain Filter Utilising HPC Architecture. [PDF]

J Imaging, 2023
Strakos P, Jaros M, Riha L, Kozubek T.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

PCNN Model Guided by Saliency Mechanism for Image Fusion in Transform Domain. [PDF]

Sensors (Basel), 2023
Liu L, Huo J.
europepmc   +1 more source

Towards Unsupervised Domain Adaptation via Domain-Transformer

International Journal of Computer Vision
As a vital problem in pattern analysis and machine intelligence, Unsupervised Domain Adaptation (UDA) attempts to transfer an effective feature learner from a labeled source domain to an unlabeled target domain. Inspired by the success of the Transformer, several advances in UDA are achieved by adopting pure transformers as network architectures, but ...
Chuan-Xian Ren, Yiming Zhai, You-Wei Luo, Hong Yan   +3 more
openaire   +2 more sources