Results 111 to 120 of about 232,984 (313)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Interdisciplinary Fairness in Imbalanced Research Proposal Topic Inference: A Hierarchical Transformer-based Method with Selective Interpolation

ACM Transactions on Knowledge Discovery from Data
The objective of topic inference in research proposals aims to obtain the most suitable disciplinary division from the discipline system defined by a funding agency. The agency will subsequently find appropriate peer-review experts from their database based on this division.
Meng Xiao 0001, Min Wu 0008, Ziyue Qiao, Yanjie Fu, Zhiyuan Ning, Yi Du, Yuanchun Zhou   +6 more
openaire   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Construction and Application of a Real-time Grid Interpolation Station Service Based on Platform Tianqing

应用气象学报
In response to the disruption of observation collection or transformation by extreme disastrous weather and subsequent destruction of automatic weather stations and communication facility, upstream and downstream relationships of grid real-time analysis ...
He Lin, Zhang Yabin, Xiao Weiqing, Huo Qing, Ji Qing, Feng Jieqiong   +5 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Effect of the Density of Measurement Points Collected From a Multibeam Echosounder on the Selection of IDW Interpolation Points in the Process of Creating Seabed Models

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The article presents the results of research on the effect of the density of measurement points (depth) from the multibeam echosounder (MBES) on the accuracy of the generated sea bottom models and the effect of this density of points on the optimal ...
Wojciech Maleika
doaj   +1 more source

Design of computationally efficient 2D FIR filters using sampling‐kernel‐based interpolation and frequency transformation [PDF]

, 2015
K.J. Kim, J.H. Kim, S.W. Nam
openalex   +1 more source

SAL-PIM: A Subarray-Level Processing-in-Memory Architecture With LUT-Based Linear Interpolation for Transformer-Based Text Generation

IEEE Transactions on Computers
Text generation is a compelling sub-field of natural language processing, aiming to generate human-readable text from input words. In particular, the decoder-only generative models, such as generative pre-trained transformer (GPT), are widely used for text generation, with two major computational stages: summarization and generation.
Wontak Han, Hyunjun Cho, Donghyuk Kim, Joo-Young Kim 0001   +3 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source