Results 71 to 80 of about 569,350 (369)

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Iterative Genetic Improvement: Scaling Stochastic Program Synthesis [PDF]

arXiv, 2022
Program synthesis aims to {\it automatically} find programs from an underlying programming language that satisfy a given specification. While this has the potential to revolutionize computing, how to search over the vast space of programs efficiently is an unsolved challenge in program synthesis.
arxiv  

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Exact Solution of the Multi-Allelic Diffusion Model

, 2005
We give an exact solution to the Kolmogorov equation describing genetic drift for an arbitrary number of alleles at a given locus. This is achieved by finding a change of variable which makes the equation separable, and therefore reduces the problem with
Baxter, G., Blythe, R. A., McKane, A. J.
core   +2 more sources

Matrix genetics, part 2: the degeneracy of the genetic code and the octave algebra with two quasi-real units (the genetic octave Yin-Yang-algebra) [PDF]

arXiv, 2008
Algebraic properties of the genetic code are analyzed. The investigations of the genetic code on the basis of matrix approaches ("matrix genetics") are described. The degeneracy of the vertebrate mitochondria genetic code is reflected in the black-and-white mosaic of the (8*8)-matrix of 64 triplets, 20 amino acids and stop-signals.
arxiv  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Advancing Crop Transformation in the Era of Genome Editing [PDF]

, 2016
Plant transformation has enabled fundamental insights into plant biology and revolutionized commercial agriculture. Unfortunately, for most crops, transformation and regeneration remain arduous even after more than 30 years of technological advances ...
Altpeter, Fredy, Bartley, Laura E., Blechl, Ann E., Brutnell, Thomas P., Citovsky, Vitaly, Conrad, Liza J., Gelvin, Stanton B., Jackson, David P., Kausch, Albert P., Lemaux, Peggy G., Medford, June I., Orozco-Cárdenas, Martha L., Springer, Nathan M., Stewart, C. Neal, Jr., Tricoli, David M., Van Eck, Joyce, Voytas, Daniel F., Walbot, Virginia, Wang, Kan, Zhang, Zhanyuan J.   +19 more
core   +1 more source

Causal relationships between milk quality and coagulation properties in Italian Holstein-Friesian dairy cattle [PDF]

, 2015
Background: Recently, selection for milk technological traits was initiated in the Italian dairy cattle industry based on direct measures of milk coagulation properties (MCP) such as rennet coagulation time (RCT) and curd firmness 30 min after rennet ...
Cassandro, Martino, Maltecca, Christian, Tiezzi, Francesco, Valente, Bruno D   +3 more
core   +4 more sources

Issues with data transformation in genome-wide association studies for phenotypic variability [v1; ref status: indexed, http://f1000r.es/1xl]

F1000Research, 2013
The purpose of this correspondence is to discuss and clarify a few points about data transformation used in genome-wide association studies, especially for phenotypic variability. By commenting on the recent publication by Sun et al.
Xia Shen, Lars Rönnegård
doaj   +1 more source

Equilibrium in Wright-Fisher models of population genetics [PDF]

Kibernetika i Sistemnyi Analiz, No. 2, March-April, 2019, pp. 96-101, 2020
For multivariant Wright-Fisher models in population genetics, we introduce equilibrium states, expressed by fluctuations of probability ratio, in contrast to the traditionally used fluctuations, expressed by the difference between the current value of the random process and its equilibrium value.
arxiv