Results 81 to 90 of about 1,895,079 (278)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Generalized nihility media from transformation optics

, 2010
Nihility media in the previous literature are usually understood as media with epsilon = mu = 0. Transformation optics opens a new perspective for capturing the essence of such media.
Yan, Wei,, Min Yan, Yan, Min,, Qiu, Min,, Min Qiu, Wei Yan   +5 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Designing optimal nanofocusing with a gradient hyperlens

Nanophotonics, 2017
We report the design of a high-throughput gradient hyperbolic lenslet built with real-life materials and capable of focusing a beam into a deep sub-wavelength spot of λ/23.
Shen Lian, Prokopeva Ludmila J., Chen Hongsheng, Kildishev Alexander V.   +3 more
doaj   +1 more source

Optical realization of the radon transform

Optics Express, 2014
This paper presents a novel optical system for the realization of the Radon transform in a single frame. The optical system is simple, fast and accurate and consists of a 4F system, where in the 2F plane a vortex like optical element is placed. This optical element performs the rotation of the object, which replaces the need for mechanically rotating ...
Tali, Ilovitsh, Asaf, Ilovitsh, John, Sheridan, Zeev, Zalevsky   +3 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A dielectric-only superstrate inspired from transformation optics for complete reorientation of electromagnetic waves in azimuthal plane

EPJ Applied Metamaterials, 2016
Various applications require an antenna to provide coverage in the azimuthal plane while still retaining a low profile. Transformation Optics method can be used to provide novel solutions to fulfill this objective. In this paper, the design of dielectric
Joshi Chetan, Lepage Anne Claire, Begaud Xavier   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Optical Darboux Transformer

Physical Review Letters
The Optical Darboux Transformer is introduced as a photonic device which performs the Darboux transformation directly in the optical domain. This enables two major advances for signal processing based on the nonlinear Fourier transform: (i) the multiplexing of different solitonic waveforms corresponding to arbitrary number of discrete eigenvalues of ...
openaire   +3 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source