Results 151 to 160 of about 85,416 (307)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Mathematical Models for Economic Estimation of Measures on Transformer’s Modernization
In paper the economic estimation of measures on modernization of transformer base using the generalized mathematical model is given. The particular mathematical models for estimation of concrete measures have been received from the generalized ...
Skobeļeva, Nataļja, Breners, Nikolajs
core
Models for the digital transformation [PDF]
Software & Systems Modeling, 2017 Jeff Gray 0001, Bernhard Rumpe
openaire +1 more source
Model transformations in Converge [PDF]
Model transformations are currently the focus of much interest and research due to the OMG’s QVT initiative. Current proposals for model transformation languages\ud can be divided into two main camps: those taking a ‘declarative’ approach, and those opting for an ‘imperative’ approach.
Tratt, Laurence, Clark, Tony
openaire
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Modelagem de transformadores em função da frequência [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Os transformadores desempenham um papel importante nos sistemas elétricos. Ao longo do tempo as técnicas de construção e
Januário, Marconi
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
A Tree-Transformer based VAE with fragment tokenization for large chemical models
Chemical language model (CLM), a molecular generation model, leverages large language models by utilizing SMILES, a string representation of compounds.
Yasubumi, Sakakibara +3 more
core +1 more source