Results 131 to 140 of about 9,555,806 (265)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The effect of transforming growth factor beta 1 (TGF-beta 1) on the regenerate bone in distraction osteogenesis - A biomechanical, histologic and immunohistochemical study on rabbits

, 2007
Distraction osteogenesis is a well established clinical treatment for limb length dicrepancy and skeletal deformities. Transforming growth factor beta 1 (TGF-beta 1) is a multifunctional peptide which controls proliferation and expression of cells ...
Feyza Unlu Ozkan, OZKAN, Feyza Unlu, Mehmet Turker, OZKAN, Korhan, Levent Eralp, Mehmet Kocaoglu, Melih Guven, SAHIN, Kemal, Türker, Mehmet, GUVEN, Melih, KOCAOGLU, Mehmet, Bilge Bilgic, ERALP, Levent, BILGIC, Bilge, Korhan Ozkan, Kemal Sahin, Bulent Ahishali, Ahishali, Bülent, Zihni Mutlu, Mutlu, Zihni   +19 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The influence of plasma TGF-beta1 levels on development of postradiotherapy fibrosis in breast cancer patients [PDF]

Archive of Oncology, 2002
Mladenović Jasmina, Borojević Nenad D., Todorović-Raković Nataša, Nešković-Konstantinović Zora, Nikolić-Vukosavljević Dragica   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Dental Occlusion as A Health Risk for Visual Acuity in Relation to Salivary Transforming Growth Factor Beta-1 ( TGF-Β1) Among Students Aged 8-10 Years

مجلة كلية الطب
Background: Correct mouth function is one of the functional matrices that contribute to the growth of the maxilla, which is connected to the growth of orbit, and vice versa.
Noor A. Ajeel Alrikabi, Ban S. Diab
doaj   +1 more source

Evaluation of transforming growth factor and vascular endothelial growth factor polymorphisms in Taiwan Chinese patients with pterygium [PDF]

, 2010
[[abstract]]PURPOSE. Pterygium is an invasive and highly vascularized growth, thought to arise from activated and proliferating limbal epithelial stem cells. Epidemiologic studies have found the increase of active angiogenic and epithelial growth factors
Bau, DT (Bau, D. -T.); Chiang, CC (Chiang, C. -C.); Tsai, YY (Tsai, Y. -Y.); Lee, CC (Lee, C. -C.); Tsai, Y (Tsai, Y.); Lin, CC (Lin, C. -C.); Tsai, CH (Tsai, C. -H.); Tsai, FJ (Tsai, F. -J.)
core  

Transforming growth factor-beta inhibits the expression of clock genes

, 2012
Disturbances of sleep-wake rhythms are an important problem in Alzheimer's disease (AD). Circadian rhythms are regulated by clock genes. Transforming growth factor-beta (TGF-β) is overexpressed in neurons in AD and is the only cytokine that is increased ...
Birchler, Thomas, Gietl, Anton, Petrzilka, Saskia, Gast, Heidemarie, Fontana, Adriano, Hock, Christoph, Müller, Andreas, Gordic, Sonja, Lopez, Martin   +8 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source