Results 81 to 90 of about 9,555,806 (265)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. [PDF]

, 2010
BACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the ...
Sambo, Maria Rosário, Carla Benchimol, Marques, Maria Isabel, Nuno Sepúlveda, Carlos Penha-Gonçalves, Maria Rosário Sambo, Maria Isabel Marques, Stefan Mustafa, Sepúlveda, Nuno, Sepúlveda Nuno, Gonçalves Lígia, Trovoada, Maria Jesus, Mustafa Stefan, Rute Velosa, Marques Maria Isabel, Velosa, Rute, António Coutinho, Benchimol, Carla, Vatúsia Quinhentos, Sambo Maria Rosário, Quinhentos Vatúsia, Oswald Wagner, Taane G Clark, Benchimol Carla, Penha-Gonçalves Carlos, Penha-Gonçalves, Carlos, Gonçalves, Lígia, Mustafa, Stefan, Coutinho, António, Maria Jesus Trovoada, Coutinho António, Clark Taane G., Lígia Gonçalves, Trovoada Maria Jesus, Quinhentos, Vatúsia, Wagner, Oswald, Wagner Oswald, Taane G. Clark, Clark, Taane G, Velosa Rute   +39 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Transforming growth factor beta family expression at the bovine feto-maternal interface

Reproductive Biology and Endocrinology, 2010
Background Endometrial remodelling is necessary for implantation in all mammalian species. The TGF beta super-family plays a crucial role in this event in humans and mice.
Herath Chandana B, Kizaki Keiichiro, Sugawara Kumiko, Hasegawa Yoshihisa, Hashizume Kazuyoshi   +4 more
doaj   +1 more source

Differential in vitro phenotype pattern, transforming growth factor-beta(1) activity and mRNA expression of transforming growth factor-beta(1) in Apert osteoblasts

, 1999
The phenotype of Apert osteoblasts differs from that of normal osteoblasts in the accumulation of macromolecules in the extracellular matrix. Apert osteoblasts increase type I collagen, fibronectin and glycosaminoglycans secretion compared with normal ...
F. Carinci, T. Baroni, F. Pezzetti, D. Martinese, E. Becchetti, M. Calvitti, L. Marinucci, P. Locci, C. Lilli   +8 more
core   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis

BMC Veterinary Research, 2013
Background Steroid Responsive Meningitis-Arteritis (SRMA) is a common cause of inflammation of the canine central nervous system (CNS). To investigate if transforming growth factor beta 1 (TGF-β1), interleukin-6 (IL-6) and vascular endothelial growth ...
Maiolini Arianna, Otten Meike, Hewicker-Trautwein Marion, Carlson Regina, Tipold Andrea   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]

, 2009
Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Takahashi, Sumio, Takeuchi, Sakae, Kanayama, Munetoshi, Maekawa, Tetsuya   +3 more
core   +1 more source