Results 131 to 140 of about 59,146 (195)

Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) Impacts Long‐Term Outcomes After Curative‐Intent Surgery for Hepatocellular Carcinoma

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1318-1332, April 2025.
Patients with HCC undergoing liver resection and meeting the new MASLD and MetALD criteria have characteristic alterations of body composition. Patients with MASLD‐HCC have similar disease‐free survival but significantly shorter OS than other HCC aetiologies after curative‐intent therapy.
Deniz Uluk, Justus Pein, Sophia Herda, Frederik Schliephake, Carolin V. Schneider, Jude Bitar, Katharina Dreher, Dennis Eurich, Ingrid W. Zhang, Lukas Schaffrath, Timo A. Auer, Federico Collettini, Cornelius Engelmann, Frank Tacke, Johann Pratschke, Isabella Lurje, Georg Lurje   +16 more
wiley   +1 more source

Fatal Acute Hemolytic Transfusion Reaction due to Anti-Wr^a. [PDF]

Transfus Med Hemother, 2018
Bahri T, de Bruyn K, Leys R, Weerkamp F.
europepmc   +1 more source

Systemic lupus erythematosus‐associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice

British Journal of Haematology, Volume 206, Issue 4, Page 1213-1217, April 2025.
Summary We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi‐organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic
Urshita Sinha, Suman Setty, Céleste Pilon, Julia J. Brown, Maria Armila Ruiz, Guohui Ren, Joyce Rauch, Santosh L. Saraf, Jerrold S. Levine   +8 more
wiley   +1 more source

Real‐world evidence of pegcetacoplan in patients with paroxysmal nocturnal haemoglobinuria: A nationwide Italian study

British Journal of Haematology, Volume 206, Issue 4, Page 1246-1249, April 2025.
In this study, we collected real‐world evidence on the use of pegcetacoplan among 22 Italian patients with paroxysmal nocturnal haemoglobinuria showing suboptimal response to anti‐C5 treatments eculizumab and ravulizumab. Most patients exhibited a complete or good response as per the criteria of the European Bone Marrow Transplant group (Risitano et al.
Elisabetta Metafuni, Filippo Achille Brioschi, Andrea Patriarca, Claudia Leoni, Giorgia Battipaglia, Daniela Carlino, Annalisa Condorelli, Valeria Di Giacomo, Sarah Marktel, Maria Antonietta Marzilli, Maurizio Miglino, Esther Natalie Oliva, Antonella Sau, Alessandra Ricco, Grazia Sanpaolo, Annarita Trolese, Anna Paola Iori, Simona Sica, Wilma Barcellini, Bruno Fattizzo   +19 more
wiley   +1 more source

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial

British Journal of Haematology, EarlyView.
Optimal red blood cell transfusion thresholds for children with bone marrow failure are uncertain. Children may be able to safely tolerate lower haemoglobin thresholds, thereby reducing transfusions, which have risks. This study in paediatric allogeneic haematopoietic stem cell transplant aimed to assess feasibility of recruitment and protocol ...
H. V. New, E. Sanderson, V. Hopkins, H. Thomas, A. Gassas, M. Adams, B. Gibson, K. Patrick, R. Wynn, L. Hoole, H. Smethurst, M. Lobo‐Clarke, L. Smith, A. Mora, S. J. Stanworth   +14 more
wiley   +1 more source

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

British Journal of Haematology, EarlyView.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs, Luiz Amorim, France Pirenne, Claude Tayou, Ijele Adimora, Lydia H. Pecker, Aaron A. R. Tobian, Jeannie Callum, Julie Makani, Mark T. Gladwin, Meghan Delaney, Darrell J. Triulzi, Isaac Odame, Evan M. Bloch   +13 more
wiley   +1 more source

Long‐term efficacy and safety of mitapivat in non‐transfusion‐dependent α‐ or β‐thalassaemia: An open‐label phase 2 study

British Journal of Haematology, EarlyView.
Mitapivat is an oral activator of pyruvate kinase (PK), the enzyme responsible for the final step in glycolysis, and increases production of adenosine triphosphate (ATP), which may lead to improvements in red blood cell health, ineffective erythropoiesis and haemolysis.
Kevin H. M. Kuo, D. Mark Layton, Ashutosh Lal, Elliott P. Vichinsky, Jayme L. Dahlin, Shihao Shen, Gavrielle M. Price, Keely S. Gilroy, Jeremie H. Estepp, Hanny Al‐Samkari   +9 more
wiley   +1 more source

Myeloid neoplasm inspired intensive therapy in VEXAS syndrome: A single‐centre experience

British Journal of Haematology, EarlyView.
Summary There is still no standard of care and unmet medical needs in refractory/advanced VEXAS (vacuoles in myeloid progenitors, E1 ubiquitin activating enzyme, X‐linked, autoinflammatory manifestations and somatic) syndrome with or without associated haematological neoplasm.
Maël Heiblig, Adriana Plesa, Juliet Tantot, Yvan Jamilloux, Hélène Labussière‐Wallet, Pierre Sujobert   +5 more
wiley   +1 more source

Intraoperative Diagnosis and Management of Acute Hypotensive Blood Transfusion Reaction (AHTR): A Report of Two Cases. [PDF]

Am J Case Rep, 2018
Yoon U, Abdullah M, Elia E, Herman J.
europepmc   +1 more source