Results 141 to 150 of about 59,146 (195)

Anti‐PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT‐like and VITT‐like characteristics

British Journal of Haematology, EarlyView.
Summary Vaccine‐induced immune thrombocytopenia and thrombosis (VITT) is one of several anti‐platelet factor 4 (anti‐PF4)‐associated immune thrombocytopenia and thrombosis (PITT) syndromes. As well as following adenoviral vector vaccines, VITT has recently been described following acute adenovirus infection.
Phillip L. R. Nicolson, Samantha J. Montague, Richard J. Buka, Anthony Calvert, Jo‐Ann I. Sheppard, Yi Zhang, Jing Jing Wang, Jack Sharman, Eman Hassan, James Harrison, Errin Lawrence, Phillip El‐Dalil, Dhruv Parekh, Husam Osman, Tom P. Gordon, Ishac Nazy, Theodore E. Warkentin, Will A. Lester   +17 more
wiley   +1 more source

Acute splenomegaly, haemolysis, and thrombocytopenia following luspatercept initiation in a patient with transfusion‐dependent thalassaemia: A case report

British Journal of Haematology, EarlyView.
Summary Patients with transfusion‐dependent thalassaemia (TDT) require chronic, life‐sustaining red blood cell transfusions, which contribute to iron overload and associated morbidity and mortality. Luspatercept, an inhibitor of the transforming growth factor‐beta pathway, decreases transfusion requirements in a subset of transfusion‐dependent β ...
Bianca Zaidel, Stephanie Garland, Hayley Merkeley   +2 more
wiley   +1 more source

Acute Hemolytic Transfusion Reaction due to Anti-P1: A Case Report and Review of Institutional Experience. [PDF]

Transfus Med Hemother, 2019
Smith D, Aye T, Er LS, Nester T, Delaney M.   +4 more
europepmc   +1 more source

Treating Hematological Malignancies With OR‐2100, an Orally Bioavailable Prodrug of Decitabine

Cancer Science, Volume 116, Issue 4, Page 853-861, April 2025.
We have developed a silylated derivative of decitabine, OR‐2100, which is resistant to degradation by cytidine deaminase and orally bioavailable. In this article, we review the current status of DNA demethylating agents for treating hematological malignancies, with a focus on OR‐2100. ABSTRACT DNA methylation is an enzyme‐driven epigenetic modification
Tatsuro Watanabe, Keisuke Kidoguchi, Shinya Kimura   +2 more
wiley   +1 more source

Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral CAR‐NK Cell Engineering

Cell Proliferation, Volume 58, Issue 4, April 2025.
This manuscript provides a comprehensive overview of the state‐of‐the‐art in non‐viral CAR‐NK cell engineering, highlighting its potential to revolutionise cancer treatment. ABSTRACT The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK ...
Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu   +18 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review

European Journal of Clinical Investigation, EarlyView.
Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina, Fábio França Vieira e Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez‐Jardón, María Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Paulo Henrique Braz‐Silva, Karem L. Ortega   +8 more
wiley   +1 more source

Avatrombopag for the Treatment of Immune Thrombocytopenia

European Journal of Haematology, Volume 114, Issue 5, Page 733-746, May 2025.
ABSTRACT Avatrombopag, a second‐generation thrombopoietin receptor agonist (TPO‐RA), represents a significant advancement in the treatment of chronic immune thrombocytopenic purpura (cITP) and a potential therapeutic option for other thrombocytopenic disorders.
Caterina Labanca, Ernesto Vigna, Enrica Antonia Martino, Antonella Bruzzese, Francesco Mendicino, Giulio Caridà, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

Medical and Nutritional Outcomes Are Similar Among Autologous Transplant Patients on Enteral Nutrition When Compared to Parenteral Nutrition. A Randomized Pilot Study

European Journal of Haematology, EarlyView.
ABSTRACT Autologous hematopoietic stem cell transplantation (AHSCT) is the treatment for myeloma and lymphoma. posttreatment, significant nutritional and medical issues and malnutrition assessed by Subjective Global Assessment (SGA) arise. No established effective treatment for using either parenteral (PN) or enteral routes (EN) to improve nutritional ...
Janet Madill, Brenda Hartman, Heather Resvick, Mehraneh Mohebbi, Alison Andrade, Cheryl Sigfrid, Maisam Abouzeeni, Adrienne Fulford, Anargyros Xenocostas, Uday Deotare   +9 more
wiley   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source