Results 281 to 290 of about 4,842,335 (379)

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma

Cancer Science, EarlyView.
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina, Masaki Ri, Yoshiaki Marumo, Tomoyuki Nakamura, Hirokazu Sasaki, Yoshiko Oshima, Takahiro Nakashima, Shinya Hagiwara, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Takaomi Sanda, Kazufumi Yamagata, Kohmei Kubo, Hirokazu Komatsu, Hirotake Sakuraba, Shinsuke Iida   +18 more
wiley   +1 more source

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation

Cancer Science, EarlyView.
ABSTRACT Succinylation has been shown to promote lung cancer development, but its mechanism remains incompletely understood. KAT2A, a succinyltransferase, acts as an oncogene in multiple cancers, but its role in mediating lung cancer progression is unclear.
Junping Li, Feng Zhao, Zhongchao Wang, Shaojun Yang, Zhichao Lu, Xiaoyan Li, Jincheng Song, Zhaoxia Dai   +7 more
wiley   +1 more source

A decade of pharmacovigilance in France: Immune checkpoints join the list of usual suspects for drug‐induced immune haemolytic anaemia

British Journal of Haematology, EarlyView.
Guillaume Brenac, Anne Dautriche, Romane Freppel, Anthony Facile, Bruno Revol, Mathilde Beurrier, Bernard Bonnotte, Sylvain Audia   +7 more
wiley   +1 more source

Expanding Access to Genome Sequencing: Higher Diagnostic Yield in Self‐Referred Participants From the CincyKidsSeq Study and Implications for Hybrid Models of Genetic Service Delivery

Clinical Genetics, EarlyView.
Genome sequencing helped find answers for 1 in 5 children with rare conditions in an outpatient study looking at hybrid genetic care delivery. Families who chose testing themselves had the highest diagnostic yield, showing that self‐referral may be a helpful way to improve access to genetic care.
Kristin Theobald, Amelle Shillington, Farrah Jackson, Jaime Lopes, Casey J. Brewer, Brian Dawson, Gang Wu, James Denton, Mike Pauciulo, Xue Zhang, Anne Slavotinek   +10 more
wiley   +1 more source

UHRF2 as a genetic correlate of hospitalization in sickle cell disease

British Journal of Haematology, EarlyView.
Mina Cintho Ozahata, Monike Oliveira, Isabel Gomes, Cláudia Maximo, Alessandra Ferraz, André Rolim Belisário, Daiane Souza, Natalia A. Braga, Ester Sabino, Brian Custer, Shannon Kelly, Carla Luana Dinardo, for the REDS‐III Brazil SCD Cohort study and the TOPMed consortium   +12 more
wiley   +1 more source

A Multicenter Observational Study for the Establishment of Novel Severity Criteria Including Endoscopic Evaluation for Intestinal Behçet's Disease

Digestive Endoscopy, EarlyView.
The establishment of novel severity criteria for intestinal Behçet's disease. ABSTRACT Objective This study aimed to establish a novel severity classification for intestinal Behçet's disease (BD) (SCIBD) and validate its criteria across multiple institutions.
Toshiro Fukui, Makoto Naganuma, Yohei Kirino, Reiko Kunisaki, Yohei Mikami, Nobuhiro Ueno, Junji Umeno, Shigeki Bamba, Makoto Ooi, Shuhei Hosomi, Takayuki Matsumoto, Katsuyoshi Matsuoka, Chikako Watanabe, Masakazu Nagahori, Motoi Uchino, Kenji Watanabe, Fumihito Hirai, Minoru Matsuura, Yoshiya Tanaka, Mitsuhiro Takeno, Tadakazu Hisamatsu   +20 more
wiley   +1 more source

Association of CTLA4 Gene Polymorphism with Transfusion Reaction after Infusion of Leukoreduced Blood Component. [PDF]

J Clin Med, 2019
Wen YH, Lin WT, Wang WT, Chiueh TS, Chen DP.   +4 more
europepmc   +1 more source

Clinical and haematological features of hyperhaemolysis in sickle cell disease: A case series from two tertiary care centres

British Journal of Haematology, EarlyView.
Jaehyup Kim, James D. Burner, Christopher Webb, Ravi Sarode, Brian D. Adkins, Margaret Kypreos, Ibrahim F. Ibrahim, Yu‐Min Shen, Sean G. Yates   +8 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Damoctocog Alfa Pegol in Severe and Nonsevere Patients With Hemophilia A From the Prospective, Multinational, Ongoing HEM‐POWR Study

European Journal of Haematology, EarlyView.
ABSTRACT Objectives To assess the effectiveness and safety of damoctocog alfa pegol in patients with severe and nonsevere hemophilia A in the fifth interim analysis of the ongoing HEM‐POWR study. Methods HEM‐POWR (NCT03932201) is a multinational, Phase 4, prospective observational study.
Mark T. Reding, María Teresa Alvarez Román, Giancarlo Castaman, Maissaa Janbain, Tadashi Matsushita, Karina Meijer, Kathrin Schmidt, Johannes Oldenburg   +7 more
wiley   +1 more source

Pseudomonas poae-Associated Fatal Septic Transfusion Reaction, Peoria, Illinois, USA, 2017. [PDF]

Emerg Infect Dis, 2019
Woodring TS, Farrell JJ.
europepmc   +1 more source