Transgenerational Transmission of Hyperactivity in a Mouse Model of ADHD [PDF]
The Journal of Neuroscience, 2014 Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder affecting children and adults. Genetic and environmental factors are associated with the etiology of ADHD. Among the environmental factors, exposure of the developing brain to nicotine is considered a major risk factor.
Jinmin, Zhu +4 more
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Present and future challenges for the investigation of transgenerational epigenetic inheritance
Environment International, 2023 Epigenetic pathways are essential in different biological processes and in phenotype-environment interactions in response to different stressors and they can induce phenotypic plasticity. They encompass several processes that are mitotically and, in some
Manon Fallet +7 more
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New normativity and reproductive choice: an attempt at comprehension [PDF]
Население и экономика, 2020 The article discusses two “special types” of reproductive choices – combating infertility through assisted reproductive technologies and voluntary childlessness. Particular attention is paid to the phenomenon of voluntary childlessness.
Svetlana A. Bronfman
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Atrazine induced epigenetic transgenerational inheritance of disease, lean phenotype and sperm epimutation pathology biomarkers. [PDF]
PLoS ONE, 2017 Ancestral environmental exposures to a variety of environmental toxicants and other factors have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The current study examined the potential transgenerational actions
Margaux McBirney +9 more
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A critical view on transgenerational epigenetic inheritance in humans
Nature Communications, 2018 Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of ...
Bernhard Horsthemke
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BMC Psychiatry, 2012 Background Over the past five decades, clinicians and researchers have debated the impact of the Holocaust on the children of its survivors. The transgenerational transmission of trauma has been explored in more than 500 articles, which have failed to ...
Braga Luciana, Mello Marcelo, Fiks José
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Tertiary Epimutations - A Novel Aspect of Epigenetic Transgenerational Inheritance Promoting Genome Instability. [PDF]
PLoS ONE, 2016 Exposure to environmental factors can induce the epigenetic transgenerational inheritance of disease. Alterations to the epigenome termed "epimutations" include "primary epimutations" which are epigenetic alterations in the absence of genetic change and "
John R McCarrey +5 more
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Chromatin resetting mechanisms preventing trangenerational inheritance of epigenetic states
Frontiers in Plant Science, 2015 Epigenetic regulation can be altered by environmental cues including abiotic and biotic stresses. In most cases, environmentally-induced epigenetic changes are transient, but in some cases they are maintained for extensive periods of time and may even be
Mayumi eIwasaki
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Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line. [PDF]
PLoS ONE, 2013 A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic transgenerational inheritance of disease and phenotypic variation.
Michael K Skinner +5 more
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The Ancestral Environment Shapes Antiviral CD8+ T cell Responses across Generations
iScience, 2019 Summary: Recent studies have linked health fates of children to environmental exposures of their great grandparents. However, few studies have considered whether ancestral exposures influence immune function across generations.
Christina M. Post +5 more
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