Results 151 to 160 of about 17,611 (257)

Root-enriched β-amylase GmBAM-like 1 enhances drought and salt tolerance in Arabidopsis. [PDF]

Genet Mol Biol
Guimarães-Dias F, Lima LL, Neves-Borges AC, Travassos-Lins J, Mantuano D, Vincentz MGA, Viana AJC, Alves-Ferreira M.   +7 more
europepmc   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

A conserved Arf-GEF modulates axonal integrity through RAB-35 by altering neuron-epidermal attachment. [PDF]

J Cell Sci
Bonacossa-Pereira I, Le D, Coakley S, Hilliard MA.   +3 more
europepmc   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Timing it right: dephosphorylation of a key transcription factor constrains the tapetal transcriptional cascade for timely pollen development. [PDF]

Plant Cell
González-Suárez P, Lara-Mondragón C.
europepmc   +1 more source

Transgenics in Indian Agriculture: Experiences so far and implications of KIA proposals on Indian Farmers

KIA proposes to bring a paradigm shift in Indian Agriculture in terms of human resource development, research, technology generation, technology dissemination and commercialization.
Ramanjaneyulu G V
core  

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

A transgenic zebrafish for spatiotemporal optogenetic activation of FGF/ERK signaling. [PDF]

Biol Open
Anderson WK, Iannucci LE, Sinaii N, Porcino J, Rogers KW.   +4 more
europepmc   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Don't make me blush: msSPX4/MsPHL11-MsWRKY91 regulates anthocyanin synthesis in Malus spectabilis under low phosphorus stress. [PDF]

Plant Physiol
Freed CP.
europepmc   +1 more source