Results 191 to 200 of about 14,109 (263)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Kv2.1 negatively regulates Reissner fiber development. [PDF]

Front Cell Dev Biol
Amini RR, Jain RP, Jędrychowska J, Korzh V.   +3 more
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Expression of a multigene mushroom luciferin biosynthesis pathway as a pseudo-polycistron in plants. [PDF]

Sci Rep
Samson D, Thompson NS, Sheri VR, Rudrabhatla SV, Curtis WR.   +4 more
europepmc   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation. [PDF]

Proc Natl Acad Sci U S A
Millán-Trejo A, Mora-Martínez C, Tarazona-Sánchez A, Lloret-Fernández C, Alis R, Jordán-Pla A, Barrios A, Flames N.   +7 more
europepmc   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Editorial: Methods in cellular neurobiology research. [PDF]

Front Cell Neurosci
Han S, Merighi A, Wang C, Chakraborti S.
europepmc   +1 more source

Shortcutting photorespiration: avenues and challenges toward realizing higher-yielding photorespiratory bypass crops. [PDF]

New Phytol
Meacham-Hensold K, Jeong J, Cavanagh AP, Ort DR.   +3 more
europepmc   +1 more source

MicroRNA169 integrates multiple factors to modulate plant growth and abiotic stress responses. [PDF]

Plant Biotechnol J
Chen X, Chen Z, Fiorentino A, Kuess M, Tharayil N, Kumar R, Leonard E, Noorai R, Hu Q, Luo H.   +9 more
europepmc   +1 more source