Results 21 to 30 of about 21,644 (216)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Designing a security-oriented leadership model of Mazandaran University of Medical Sciences [PDF]

مدیریت و چشم انداز آموزش
The goal is designing a security-oriented leadership model of Mazandaran University of Medical Sciences, which is a fundamental study in terms of research orientation, and a mixed exploratory one in terms of data analysis method.
Saeid Miladigorji, Mohammad Hassan Shakki, Mojtaba Rezaei Rad   +2 more
doaj   +1 more source

Effect of Innovative Capabilities on Transient Competitive Advantage among Hospitals in Kenya

The University Journal
This paper examined the effect of innovative capabilities on transient competitive advantages of private hospitals in Kenya. The study addresses the competitive challenges faced by private hospitals in Kenya targeting 476 private hospitals’ top managers. The findings presented in this paper were drawn from 209 hospital managers.
Evalyne Khamasi Amboyi, Veronica Kaluyu, Gabrielle Okello   +2 more
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Knowledge Audit and Transient Competitive Advantage in Textile Manufacturing Firms in Kenya

The University Journal
The textile industry can advance the country's economic standing by offering work opportunities and contributing to the country's gross domestic product. Nevertheless, the textile sector in Kenya has not achieved the anticipated levels of growth. This paper aimed to investigate the influence of knowledge audit on the transient competitive advantage of ...
Yusuf Saleh, Joseph Ngugi Kamau
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Unveiling pathways: exploring chronological and maturational biases in a Spanish professional soccer academy

Frontiers in Sports and Active Living
This brief research report aimed to analyze the prevalence of asymmetries in players' date of birth, the influence of relative age affects (RAEs) and maturation on players' participation, and the potential maturity biases in performance indicators in a ...
Saúl Peñín-Grandes, Saúl Peñín-Grandes, Silvia Mesonero-García, Florentino Huertas Olmedo, Honorato Jose Ginés Cabeza, Rafael Ballester Lengua   +5 more
doaj   +1 more source

Effect of Technological Capabilities on Transient Competitive Advantage among Hospitals in Kenya

The University Journal
This research aimed to address a significant gap by empirically examining the link between technological capabilities and transient competitive advantage, a topic largely overlooked in the Kenyan healthcare sector. The study combined descriptive and correlational research designs.
Evalyne Khamasi Amboyi, Veronica Kaluyu, Gabrielle Okello   +2 more
openaire   +1 more source

The Influence of Business Environment and Capabilities on Transient Competitive Advantage and Their implications for Business Performance of Micro, Small and Medium Enterprises in Indonesia

International Journal of Engineering & Technology, 2018
Micro, small and medium enterprises (MSME – Indonesian: UMKM – Usaha Micro, Kecil dan Menengah) are the key to increase growth, create employment, act as the source of people’s income, to fulfil the need of goods and services, to increase the added values which eventually influence the economic growth.
Nurul Hermina, Adjeng Mariana, Keni Kaniawati   +2 more
openaire   +2 more sources