Results 21 to 30 of about 23,036 (216)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Extinction Debt and Colonizer Credit on a Habitat Perturbed Fishing Bank.

PLoS ONE, 2016
Temporal changes in occupancy of the Georges Bank (NE USA) fish and invertebrate community were examined and interpreted in the context of systems ecological theory of extinction debt (EDT). EDT posits that in a closed system with a mix of competitor and
Daniel E Duplisea, Michael G Frisk, Verena M Trenkel   +2 more
doaj   +1 more source

Effect of Innovative Capabilities on Transient Competitive Advantage among Hospitals in Kenya

The University Journal
This paper examined the effect of innovative capabilities on transient competitive advantages of private hospitals in Kenya. The study addresses the competitive challenges faced by private hospitals in Kenya targeting 476 private hospitals’ top managers. The findings presented in this paper were drawn from 209 hospital managers.
Evalyne Khamasi Amboyi, Veronica Kaluyu, Gabrielle Okello   +2 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Knowledge Audit and Transient Competitive Advantage in Textile Manufacturing Firms in Kenya

The University Journal
The textile industry can advance the country's economic standing by offering work opportunities and contributing to the country's gross domestic product. Nevertheless, the textile sector in Kenya has not achieved the anticipated levels of growth. This paper aimed to investigate the influence of knowledge audit on the transient competitive advantage of ...
Yusuf Saleh, Joseph Ngugi Kamau
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Influence of Business Environment and Capabilities on Transient Competitive Advantage and Their implications for Business Performance of Micro, Small and Medium Enterprises in Indonesia

International Journal of Engineering & Technology, 2018
Micro, small and medium enterprises (MSME – Indonesian: UMKM – Usaha Micro, Kecil dan Menengah) are the key to increase growth, create employment, act as the source of people’s income, to fulfil the need of goods and services, to increase the added values which eventually influence the economic growth.
Nurul Hermina, Adjeng Mariana, Keni Kaniawati   +2 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Unveiling pathways: exploring chronological and maturational biases in a Spanish professional soccer academy

Frontiers in Sports and Active Living
This brief research report aimed to analyze the prevalence of asymmetries in players' date of birth, the influence of relative age affects (RAEs) and maturation on players' participation, and the potential maturity biases in performance indicators in a ...
Saúl Peñín-Grandes, Saúl Peñín-Grandes, Silvia Mesonero-García, Florentino Huertas Olmedo, Honorato Jose Ginés Cabeza, Rafael Ballester Lengua   +5 more
doaj   +1 more source