Results 81 to 90 of about 1,538,403 (301)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current

BMC Pharmacology and Toxicology
Background Topiramate (TPM) is a sulfamate-substituted monosaccharide known for its wide-ranging effects on epilepsy, neuropathic pain, and migraines.
Ray-Chang Tzeng, Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang   +3 more
doaj   +1 more source

Uranium Dissolution Behavior in LiCl-KCl Molten Salts

International Journal of Electrochemical Science, 2017
Uranium (U) dissolution behavior at an anode during electrorefining was investigated by employing the potentiodynamic polarization method, galvanostatic potential transient technique, AC impedance spectroscopy, and potentiostatic current transient ...
Sung-Jai Lee, Gha-Young Kim
doaj   +1 more source

Transient current spectroscopy of a quantum dot in the Coulomb blockade regime

, 2000
Transient current spectroscopy is proposed and demonstrated in order to investigate the energy relaxation inside a quantum dot in the Coulomb blockade regime.
A. V. Khaetskii, D. D. Awschalom, D. Loss, D. R. Stewart, J. A. Gupta, J. Weis, L. P. Kouwenhoven, N. C. van der Vaart, O. Agam, S. Komiyama, S. Sasaki, S. Tarucha, T. Fujisawa, T. Fujisawa, T. H. Oosterkamp, Toshimasa Fujisawa, U. Bockelmann, Yasuhiro Tokura, Yoshiro Hirayama   +18 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons

Frontiers in Neurology
Vestibular afferent neurons occur as two populations with differences in spike timing regularity that are independent of rate. The more excitable regular afferents have lower current thresholds and sustained spiking responses to injected currents, while ...
Selina Baeza-Loya, Ruth Anne Eatock
doaj   +1 more source

Transient Elastography in Canada: Current State and Future Directions

Canadian Journal of Gastroenterology and Hepatology, 2015
BACKGROUND: Transient elastography (TE) is a safe and effective technology to noninvasively assess hepatic fibrosis in patients with numerous liver conditions.
Mohammed Aljawad, Sanjeev Sirpal, Eric M Yoshida, Natasha Chandok   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Analysing Electrophoretic Deposition Using Transient Current Measurements

, 2022
Electrophoretic deposition (EPD) is a widely used technique for coating surfaces with colloidal particles [1]. When using apolar solvents, one or more surfactants are required as charging agents. These surfactant molecules do not only adsorb to the particles, assisting in particle charging, but also aggregate into inverse micelles of which a small ...
Delporte, Rogier, Strubbe, Filip, Neyts, Kristiaan   +2 more
openaire   +2 more sources