Results 91 to 100 of about 1,147,249 (305)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Modelling pressure fluctuations during flow boiling in microchannels with inlet compressibility and resistance [PDF]
, 2009 Confined bubble growth during flow boiling at low pressures in microchannels generates pressure fluctuations that may cause transient flow reversals that disturb the flow distribution in heat sinks formed of parallel channels joined by plena.
Gedupudi, S +2 more
core
Nonmodal energy growth and optimal perturbations in compressible plane Couette flow
, 2008 Nonmodal transient growth studies and estimation of optimal perturbations have been made for the compressible plane Couette flow with three-dimensional disturbances.
J. Dey +3 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Numerical Simulation of Transient Multiphase Flow in a Five-Strand Bloom Tundish during Ladle Change
Metals, 2018 The steel-slag-air multiphase flow in a bloom tundish with five strands during the transient casting of the ladle change was simulated using the Volume of Fluid (VOF) model, and the formation mechanisms of macro-inclusions and the behavior of the steel ...
Hua Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Engineering Applications of Computational Fluid MechanicsControlling pressure impact of water hammer is an important guarantee for safe and stable running of pipeline systems. Previously, we proposed a spring self-adaptive auxiliary control (SAC) system to improve the pressure control ability of a surge tank ...
Boran Zhang +7 more
doaj +1 more source
New computer program solves wide variety of heat flow problems [PDF]
, 1966 Boeing Engineering Thermal Analyzer /BETA/ computer program uses numerical methods to provide accurate heat transfer solutions to a wide variety of heat flow problems.
Almond, J. C.
core +1 more source