Results 71 to 80 of about 418,767 (267)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MATHEMATICAL MODELING FOR WATER HAMMER IN PIPE FLOW

Journal of Engineering and Sustainable Development, 2018
Water hammer phenomenon is a transient flow in pipes that was created by rapid changes of velocity in pipelines. This phenomenon can be caused strong positive and negative pressures in water pipelines.
Qassem H. jalut, Nisreen J. Rasheed
doaj  

Correction Factors for the Use of 1D Solution Methods for Dynamic Laminar Liquid Flow through Curved Tubes

Fluids
The modeling of transient flows of liquids through tubes is required for studies in water hammer, switched inertance hydraulic converters, and noise reduction in hydraulic equipment.
Travis Wiens
doaj   +1 more source

Investigation of Water Hammer Protection in Water Supply Pipeline Systems Using an Intelligent Self-Controlled Surge Tank

Energies, 2018
A surge tank is a common pressure control device in long pressurized pipelines. The performance is greatly influenced by the location, cross area, and the characteristics of the connector. In order to improve the property of the surge tank, the effect of
Wuyi Wan, Boran Zhang
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A transient production prediction method for tight condensate gas wells with multiphase flow

Petroleum Exploration and Development
Considering the phase behaviors in condensate gas reservoirs and the oil-gas two-phase linear flow and boundary-dominated flow in the reservoir, a method for predicting the relationship between oil saturation and pressure in the full-path of tight ...
Wenpeng BAI, Shiqing CHENG, Yang WANG, Dingning CAI, Xinyang GUO, Qiao GUO   +5 more
doaj   +1 more source

Analytical modification of EDFM for transient flow in tight rocks. [PDF]

Sci Rep, 2022
Olorode O, Rashid H.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical Modeling of Transient Flow Characteristics on the Top Surface of a Steel Slab Continuous Casting Strand Using a Large Eddy Simulation Combined with Volume of Fluid Model. [PDF]

Materials (Basel), 2023
Tian Y, Zhou H, Wang G, Xu L, Qiu S, Zhu R.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source