Results 81 to 90 of about 418,767 (267)

Effectiveness of splitter plate to control fluid forces on a circular obstacle in a transient flow: FEM computations. [PDF]

Sci Rep, 2022
Ain QU, Mahmood R, Awrejcewicz J, Siddique I, Majeed AH, Pawłowski W.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Theoretical investigation of hybrid nanomaterials transient flow through variable feature of Darcy-Forchheimer space with exponential heat source and slip condition. [PDF]

Sci Rep, 2022
Ullah I, Alajlani Y, Pasha AA, Adil M, Weera W.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Numerical Simulation of Transient Behavior of Downhole Centrifugal Supercharging Device during Flow Sharp Reduction Process

Shiyou jixie, 2017
The complex and changeable downhole environment makes the robot conveying tool is easy to stuck, leading to the instantaneous work abrupt change of robot. In order to study the influence of flow abrupt change on the external transient characteristics and
Ren Shuai, Liu Mingyao, Zhang Guofeng, Chen Xia   +3 more
doaj  

Transient Pressure Performance Analysis of Hydraulically Fractured Horizontal Well in Tight Oil Reservoir

Energies
Utilizing the discrete fracture model (DFM), a transient flow model is established for fractured horizontal wells in tight oil reservoirs, accounting for threshold pressure gradient (TPG), stress sensitivity effect, hydraulic fracture parameters, and ...
Lichun Sun, Maojun Fang, Weipeng Fan, Hao Li, Longlong Li   +4 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

NUMERICAL SIMULATION OF TRANSIENT FLOW IN STORM SEWERS USING STANDARD AND IMPROVED MCCORMACK SCHEME

TASK Quarterly, 2012
This paper describes the results of the first part of the research project which aims at developing a hydraulic model for simulation of unsteady flows in storm sewers ranging from gravity flows to surcharged flows resulting with water outflow on the ...
MICHAŁ SZYDŁOWSKI, JUSTYNA MACHALIŃSKA-MURAWSKA   +1 more
doaj