Results 81 to 90 of about 697,673 (264)

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Real‐World Cost and Utilisation Burden of Diagnosed Metabolic Dysfunction‐Associated Steatotic Liver Disease in Patients With Type 2 Diabetes in the United States: A Retrospective Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study quantified the real‐world healthcare costs and utilisation associated with diagnosed metabolic dysfunction‐associated steatotic liver disease (MASLD) among adults with Type 2 diabetes (T2D). Methods We conducted a retrospective cohort study using IQVIA PharMetrics Plus Closed Health Plan data from January 2016 to June 2025 ...
Tien Hoang Tran, Hyung‐Seok Kim, Rozalina G. McCoy, Zafar Zafari   +3 more
wiley   +1 more source

Characterization of thyroid-stimulating blocking antibodies that appeared during transient hypothyroidism after radioactive iodine therapy [PDF]

, 2000
Hypothyroidism after radioactive iodine (RAI) therapy for Graves' disease can be transient or permanent. The cause for early transient hypothyroidism is unknown.
Kohn, LD, Kung, AWC, Annie W. C. Kung, Lau, KS, Ld. Kohn, K. S. Lau   +5 more
core   +1 more source

Neuropsychiatric Outcomes Associated With GLP‐1 Receptor Agonist Use in Medicare Beneficiaries With Type 2 Diabetes: Variation by Treatment Pattern and Obesity Status

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptors are expressed in brain regions governing mood, reward and stress, yet the neuropsychiatric effects of GLP‐1 receptor agonist (GLP‐1 RA) therapy remain poorly characterized. We estimated associations between GLP‐1 RA use and neuropsychiatric disorders and variation by obesity status and treatment ...
Seo Hyon Baik, Fitsum Baye, Haotian Xian, Kin Wah Fung, Clement J. McDonald   +4 more
wiley   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Prevalence of Transient Hypothyroidism in Children Diagnosed with Congenital Hypothyroidism between 2000 and 2016. [PDF]

Int J Mol Sci, 2023
Gmür S, Konrad D, Fingerhut R.
europepmc   +1 more source

Association of Aspirin With Improved Clinical Outcomes and Survival in Patients With Compensated Cirrhosis: A Propensity Score‐Matched Study of 25 782 Individuals

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Pharmacologic therapies to prevent decompensation in cirrhosis remain limited. Aim To evaluate the association between aspirin use and cirrhosis‐related outcomes and mortality. Methods This retrospective cohort study utilized deidentified electronic health records from a global federated network (January 2013–July 2025). Adults with
Shahem Abbarh, Bisher Sawaf, Tiago Lemos Cerqueira, Hagen B. Huttner, Annahita Sedghi, Norma J. Diel, Timo Siepmann   +6 more
wiley   +1 more source

[Transient congenital hypothyroidism: physiopathology and clinica].

, 1998
The fetus and the newborn are more sensitive than adults to a reduced environmental iodine supply, and in iodine-deficient areas, transient neonatal hypothyroidism is frequently observed.
Pinchera A, Montanelli L, CHIOVATO, LUCA, SANTINI, FERRUCCIO, Cavaliere R, Santini F, Vitti P, VITTI, PAOLO, Chiovato L.   +8 more
core  

Etiological evaluation of primary congenital hypothyroidism cases

, 2017
Aim: Primary congenital hypothyroidism is frequently seen endocrine disorder and one of the preventable cause of mental retardation. Aim of study was to evaluate the frequency of permanent/transient hypothyrodism, and to detect underlying reason to ...
Nese Torun, Dilek, Emine, Digdem Bezen, Bezen, Digdem, Emine Dilek, Tutunculer, Filiz, Torun, Nese, Filiz Tutunculer   +7 more
core   +1 more source

Validating a Wearable Bluetooth Oximeter for Infants in the Neonatal Intensive Care Unit

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Introduction Oxygen is vital for life but the wrong amount of oxygen can lead to significant risk of morbidity and mortality. Preterm infants are at particular risk from both too little (hypoxia) and excess (hyperoxia) oxygen. In the neonatal intensive care unit (NICU), oxygen treatment is guided by oximetry derived from wired oximeters which ...
Amy Courtney, Ju Lee Oei
wiley   +1 more source