Results 71 to 80 of about 1,630,214 (246)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Characteristics and Optimization of Transient Process of Pump-Turbine Units in Power Generation Mode

Energies
Pumped storage power is considered an ideal regulated power source for new energy. However, the traditional one-dimensional characteristic line method cannot predict the pulsating pressure caused by the reverse “S” characteristic of a pump–turbine.
Minglu Zhang, Jie Liu, Junqin Yu, Changhua Nie   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Determination of loads on perforated tank partition

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2020
The article presents a solution to the problem of dynamic loading of a perforated partition located in the fuel tank of a launch vehicle. A technique for calculating the dynamic loading of the partition is described. Its equation of motion was decomposed
A. G. Filipov, I. E. Glazkov
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Investigation of Gas Natural Separation Process Unsteady Features by Means of an Experimental Rig and Mathematical Modeling

Georesursy
Natural gas separation is an important process in wells equipped with electric submersible pumps (ESP) that affects the efficiency of the «wellbore-pump-tubing» system.
V. A. Ivanov, V. S. Verbitsky, R. A. Khabibullin, K. A. Goridko, E. I. Nikonov   +4 more
doaj   +1 more source

Heat transfer in a recirculation zone at steady-state and oscillating conditions - the back facing step test case [PDF]

, 2008
Steady state and transient heat transfer is a very important aspect of any combustion process. To properly simulate gas to wall heat transfer in a turbulent flow, an accurate prediction of the flow and the thermal boundary layer is required.
Kok, J.B.W., Meer, T.H. van der, Panara, D., Pozarlik, A.K.   +3 more
core   +1 more source