Results 171 to 180 of about 983,653 (300)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Uncovering the rapidly evolving orbits of the dynamic TOI-201 system. [PDF]

Sci Adv
Mireles I, Ulmer-Moll S, Liveoak D, Dragomir D, Korth J, Venner A, Collins KA, Triaud AHMJ, Guillot T, Petit A, Carmichael T, Millholland S, Hallatt T, Parviainen H, Osborn HP, Rapetti D, Baycroft TA, Bhatnagar S, Bouchy F, Dancikova R, Figueira P, Lendl M, Udry S, Wheatley P, Abe L, Agabi A, Beltrame M, Bendjoya P, Deloupy V, Mékarnia D, Schmider FX, Suárez O, Barkaoui K, Horne K, Murgas F, Palle E, Schwarz RP, Sefako R, Shporer A, Srdoc G, Stockdale C, Wilkin FP, Hartman JD, Sgro LA, Tan TG, Jenkins JM, Bódi A, Havell D, Rivett D, Transom I.   +49 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Unlocking the colon clock: Bridging the gap in colonic transit time studies for optimal management of chronic constipation. [PDF]

World J Gastrointest Pharmacol Ther
Kalra S, Goyal MK, Goyal K, Singh R, Vuthaluru AR, Goyal O.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Signed, sealed, delivered: a generalizable model for living biotherapeutic dosing and metabolism. [PDF]

NPJ Syst Biol Appl
DeVito VL, Karamched BR.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Does in-transit feeding of day-old chicks enhance potato peel meal utilization? Impact on transport stress, gastrointestinal organ weight and performance in broilers. [PDF]

Poult Sci
Li X, Lu J, Rathgeber B, Rogiewicz A, Collins S.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Back-to-base Versus In-transit Machine Perfusion in Donation After Circulatory Death Liver Transplantation: Insights From a National Registry. [PDF]

Transplant Direct
Alderete IS, Gao Q, Aykun N, Diab MM, Abraham N, Raigani S, Shaw B, Rege A, McElroy L, Vikraman D, Ravindra K, Collins BH, Knechtle SJ, Sudan DL, Barbas AS.   +14 more
europepmc   +1 more source