Results 41 to 50 of about 196,358 (253)
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Migration retour ou migration détour ?
Return or Detour? On the diversity of migration trajectories among Brazilians of Japanese descent. This article calls into question the categorization as a “return migration” of the migration of Brazilians of Japanese descent (Nikkei or Nikkeijin) to ...
Mélanie Perroud
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Generating hope through activity
This article examines the way Somali refugees cope with their situation under uncertain circumstances in their transit country, more particularly, the Eastleigh Estate, Nairobi, Kenya, where they wait for resettlement to a third country in a process ...
Lena Johansson
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The concepts of enclave and exclave and their use in the political and geographical characteristic of the Kaliningrad region [PDF]
This article focuses on the genesis of and correlation between the related concepts of enclave and exclave and the scope of their use in different sciences, fields of knowledge, and everyday speech.
Rozhkov-Yuryevsky Yuri
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Estimating the Contribution of the Summer Traffic Peak to PM2.5, NOx, and NMVOCs
Air quality is becoming an important asset of modern society. Europe is adopting regulations that will enable better air quality for residents and encourage detailed study of emissions sources.
Petra Dolšak Lavrič, Andreja Kukec
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source

