Results 111 to 120 of about 308,788 (299)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The interactin between tolls and capacity investment in serial and parallel transport networks [PDF]

open access: yes
The purpose of this paper is to compare the interaction between pricing and capacity decisions on simple serial and parallel transport networks. When individual links of the network are operated by different regional or national authorities, toll and ...
Bruno De Borger   +2 more
core  

Class Act: An Assessment of Los Angeles Metro’s U-Pass Program [PDF]

open access: yes, 2019
In 2016, the Los Angeles County Metropolitan Transportation Authority (Metro) introduced the Universal College Student Transit Pass (U-Pass), its reduced transit fare pass program for college and university students, with the expressed goal of increasing
Yowell, T. Ryan
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Evaluation and Diagnosis of Suzhou Rail Transit Passenger Flow from the Perspective of Supply-Demand Balance

open access: yesChengshi guidao jiaotong yanjiu
[Objective] By the end of 2022, the rail transit system in Suzhou had essentially formed a network. However, the overall passenger flow has remained relatively low, necessitating an evaluation of the passenger flow on Suzhou rail transit to identify key ...
JIN Ming, SHI Min, LI Zhekang, LI Xu
doaj   +1 more source

Real-Time Integrated Limited-Stop and Short-Turning Bus Control with Stochastic Travel Time

open access: yesJournal of Advanced Transportation, 2017
In a traditional transit system, passenger arrival time and bus running time are typically random and uncoordinated. This randomness gives the appearance of unbalanced passenger demand and unreliable transit services.
Hu Zhang   +4 more
doaj   +1 more source

Public Versus Private Mobility for the Poor: Transit Improvements Versus Increased Car Ownership in the Sacramento Region, MTI Research Report 08-02 [PDF]

open access: yes, 2009
Whether to aid welfare recipients in overcoming transportation barriers with increased car ownership or better transit became an issue after the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 was signed into law.
Gao, Shengyi, Johnston, Robert A.
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Multiobjective Transit Network Design With Travel Time Reliability for Conventional and Autonomous Electric Vehicles

open access: yesIEEE Access
This study addresses the multiobjective transit network design and frequency setting problem, aiming to improve travel time reliability under urban congestion. Digital tachograph data collected from a large fleet are utilized to assess the variability of
Su Jin Park, Seungmo Kang
doaj   +1 more source

Urban Rail Transit Scheduling under Time-Varying Passenger Demand

open access: yesJournal of Advanced Transportation, 2018
In view of the conflict between the time-variation of urban rail transit passenger demand and the homogeneity of the train timetable, this paper takes into account the interests of both passengers and operators to build an urban rail transit scheduling ...
Xing Zhao   +4 more
doaj   +1 more source

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