Energy Trade and Cooperation Between the EU and CIS Countries [PDF]
The report reviews key issues in energy trade and cooperation between the EU and CIS countries. It describes historical trends of oil and gas demand in the EU, other European and CIS countries and offers demand forecasts until 2030.
Leonid Grigoriev +5 more
core
Transportation Systems Evaluation [PDF]
, 1972 A methodology for the analysis of transportation systems consisting of five major interacting elements is reported. The analysis begins with the causes of travel demand: geographic, economic, and demographic characteristics as well as attitudes toward ...
Fanning, M. L., Michelson, R. A.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Healthy Corridor for All: A Community Health Impact Assessment of Transit-Oriented Development Policy in Saint Paul, Minnesota [PDF]
, 2011 Details the connections between land-use decisions and health and equity outcomes based on a health impact assessment of the Central Corridor light rail line in the Twin Cities.
Danielle Bergstrom, Shireen Malekafzali
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
An optimized two‐phase demand‐responsive transit scheduling model considering dynamic demand
IET Intelligent Transport SystemsDemand‐responsive transit has gradually attracted attention in recent years for its flexibility, efficiency, and ability to meet the diverse travel demands of passengers.
Cui‐Ying Song +3 more
doaj +1 more source
Options for Transporting Russian Gas to Western Europe: A Game-theoretic Simulation Analysis [PDF]
This paper examines the perspectives of Russian gas exports to Western Europe and the strategic options of the CIS gas transiting countries, namely Ukraine and Belarus.The development of a new transit corridor through Belarus (the Yamal-Europe pipeline),
Andreas Chollet +3 more
core
Improving Livability Using Green and Active Modes: A Traffic Stress Level Analysis of Transit, Bicycle, and Pedestrian Access and Mobility [PDF]
, 2017 Understanding the relative attractiveness of alternatives to driving is vitally important toward lowering driving rates and, by extension, vehicle miles traveled (VMT), traffic congestion, greenhouse gas (GHG) emissions, etc.
Appleyard, Bruce +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source