Results 71 to 80 of about 120,987 (267)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Stochastic User Equilibrium Assignment in Schedule-Based Transit Networks with Capacity Constraints

Discrete Dynamics in Nature and Society, 2012
This paper proposes a stochastic user equilibrium (SUE) assignment model for a schedule-based transit network with capacity constraint. We consider a situation in which passengers do not have the full knowledge about the condition of the network and ...
Wangtu Xu, Lixin Miao, Wei-Hua Lin
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Interpreting Regional Functions Around Urban Rail Stations by Integrating Dockless Bike Sharing and POI Patterns: Case Study of Beijing, China

Urban Science
Identifying area functions around urban rail transit (URT) stations is crucial for optimizing urban planning and infrastructure allocation. Traditional methods relying on static land-use data fail to capture dynamic human–environment interactions, while ...
Siyang Liu, Jian Rong, Chenjing Zhou, Miao Guo, Haodong Sun   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evaluation of Transfer Space Efficiency of Metro Stations in Renovation Projects Using Virtual Wayfinding Tasks and User Satisfaction Surveys

Promet (Zagreb)
Recently, rail transit stations have been actively integrated with the surrounding business environment in the pre-design stage, showing scale, diversity and integration.
Yimeng ZHAO, Haishan XIA, Ran XU
doaj   +1 more source

Developing an Extenics-Based Model for Evaluating Bus Transit System

Journal of Advanced Transportation, 2020
Evaluating bus transit performance periodically is a key step to improve service quality and system efficiency. An extenics-based model is developed with the real-world data. The performance indices employed for the evaluation are identified.
Yufeng Liu, Steven Chien, Dawei Hu, Ning Wang, Rui Zhang   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimizing Transit Network Departure Frequency considering Congestion Effects

Journal of Advanced Transportation
This paper introduces a bilevel programming model for optimizing transit network departure frequency. In the upper-level model, user satisfaction is reflected by considering congestion effects in the cost function.
Wei Tan, Xiaodong Peng, Jun Huang, Yuwen Wang, Jiandong Qiu, Xiaobo Liu   +5 more
doaj   +1 more source