Results 41 to 50 of about 91,119 (345)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Optimization of a hierarchical hub and satellite network for urban freight on transit

npj Sustainable Mobility and Transport
Growing urban populations drive the demand for urban goods movement, prompting interest in innovative urban logistics solutions. This study explores integrating passenger and freight transport by using public transport—the urban rail network—for parcel ...
Meijing Zhang, Lynette Cheah
doaj   +1 more source

bRing: An observatory dedicated to monitoring the $\beta$ Pictoris b Hill sphere transit [PDF]

, 2017
Aims. We describe the design and first light observations from the $\beta$ Pictoris b Ring ("bRing") project. The primary goal is to detect photometric variability from the young star $\beta$ Pictoris due to circumplanetary material surrounding the ...
Bailey III, J. I., Crawford, S. M., Dorval, P., Ireland, M. J., Kenworthy, M. A., Laginja, I., Lomberg, B. B. D., Mamajek, E. E., Mellon, S. N., Stuik, R., Talens, G. J. J.   +10 more
core   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Super-Earth Transiting a Naked-Eye Star [PDF]

, 2011
We have detected transits of the innermost planet "e" orbiting 55 Cnc (V=6.0), based on two weeks of nearly continuous photometric monitoring with the MOST space telescope.
Batalha, Butler, Carter, Dawson, Demory, Fischer, Gilliland, Hatzes, Holman, Ji, Li, Mandel, Marcus, Marcy, McArthur, Novak, Nutzman, Seager, Takeda, Valenti, von Braun, Winn, Winn, Wisdom   +23 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Hinode Calibration for Precise Image Co-alignment between SOT and XRT (November 2006 -- April 2007)

, 2007
To understand the physical mechanisms for activity and heating in the solar atmosphere, the magnetic coupling from the photosphere to the corona is an important piece of information from the Hinode observations, and therefore precise positional alignment
DeLuca, Edward E., Ichimoto, Kiyoshi, Kano, Ryohei, Katsukawa, Yukio, Lundquist, Loraine L., Matsuzaki, Keiichi, Minesugi, Kenji, Sakao, Taro, Shimizu, Toshifumi, Shine, Richard A., Soma, Mitsuru, Tarbell, Theodore D., Tsuneta, Saku, Weber, Mark A.   +13 more
core   +1 more source

GJ 1252 b: A 1.2 R\u3csub\u3e⊕\u3c/sub\u3e Planet Transiting An M3 Dwarf At 20.4 pc [PDF]

, 2020
We report the discovery of GJ 1252 b, a planet with a radius of 1.193 ± 0.074 R⊕ and an orbital period of 0.52 days around an M3-type star (0.381 ± 0.019 M⊕, 0.391 ± 0.020 R⊕) located 20.385 ± 0.019 pc away.
Anderson, D. R., Armstrong, J. D., Astudillo-Defru, N., Bonfils, X., Charbonneau, D., Cloutier, R., Collins, K. A., Collins, K. I., Colon, K., Daylan, T., Dressing, C. D., Gan, T., Günther, M. N., Hellier, C., Horne, K., Huang, C. X., Irwin, J., Jenkins, J. M., Jensen, Eric L.N., Kielkopf, J., Latham, D. W., Léepine, S., Matthews, E., Muirhead, P. S., Palle, E., Ricker, G. R., Rose, M. E., Seager, S., Sefako, R., Shporer, A., Stassun, K. G., Tan, T.-G., Twicken, J. D., Vanderburg, A., Vanderspek, R., Villasenor, J. N., Winn, J. N., Winters, J. G.   +37 more
core   +1 more source

A new view on exoplanet transits: Transit of Venus described using three-dimensional solar atmosphere Stagger-grid simulations [PDF]

, 2015
Stellar activity and, in particular, convection-related surface structures, potentially cause fluctuations that can affect the transit light curves. Surface convection simulations can help the interpretation of ToV.
Asplund, M., Chiavassa, A., Collet, R., Faurobert, M., Magic, Z., Pere, C., Ricort, G., Tanga, P.   +7 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source