Results 141 to 150 of about 14,727,172 (294)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Capillary transit time heterogeneity comes into focus. [PDF]

Proc Natl Acad Sci U S A
Boas DA.
europepmc   +1 more source

Transit in Washington, D.C.: Current Benefits and Optimal Level of Provision [PDF]

The discrepancy between transit’s large share of local transportation resources and its generally low share of local trips has raised questions about the use of scarce transportation funds for this purpose.
Harrington, Winston, Safirova, Elena, Nelson, Peter, Lipman, Abram, Bagliano, Andrew   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Colon Capsule Endoscopy-Measured Colonic Transit Time Is Associated with Frailty in Older Adults. [PDF]

Medicina (Kaunas)
Nakaji K, Kumamoto M, Nakae Y.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Intestinal transit time phenotype is not transferred through gut microbiota transplantation. [PDF]

PeerJ
Hjørne AP, Moretti CH, Greiner TU, Procházková N, Roager HM, Mortensen MS, Bäckhed F, Licht TR, Laursen MF.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Imaging Venous Transit Time and Blood-Brain Barrier Permeability of the Deep Brain. [PDF]

Magn Reson Med
Shi W, Song J, Wu J, Gou Y, Hu Z, Yedavalli V, Lin Z, Lu H.   +7 more
europepmc   +1 more source

University Traveler Value of Potential Real-Time Transit Information

, 2011
Intelligent transportation systems (ITS) have become common in public transit systems, particularly providing real-time transit information. For new implementations, it remains difficult to predict and quantify system and user benefits of technology ...
Fries, Ryan N., Chowdhury, Mashrur A., Dunning, Anne E.   +2 more
core