Results 71 to 80 of about 14,727,172 (294)
DEVELOPMENT OF TIME-OF-DAY-BASED TRANSIT ACCESSIBILITY ANALYSIS TOOL
, 2002 The measurement of transit accessibility and availability is important both for forecasting transit ridership and for planning and evaluating transit service.
Pendyala, Ram M +2 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Cybersecurity Resilience Assessment Tool to Enhance Public Confidence in Transit [PDF]
I n 2021, the Federal Transit Administration (FTA) awarded the Rock Island County Metropolitan Mass Transit District (MetroLINK) a grant to develop a cybersecurity assessment tool to assess its cyber posture as part of FTA\u2019s Public Transportation ...
Thomas, Brandon +6 more
core +1 more source
Importance of vegetation, topography and flow paths for water transit times of base flow in alpine headwater catchments [PDF]
, 2013 The mean transit time (MTT) of water in a catchment gives information about storage, flow paths, sources of water and thus also about retention and release of solutes in a catchment.
M. H. Mueller +7 more
core +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An Overview of Computational Fluid Dynamics as a Tool to Support Ultrasonic Flow Measurements
MetrologyUltrasonic flow meters (UFMs) by transit time are ubiquitous in industrial applications, mainly for their versatility and practicality. They are widely used in gas and liquid installations, such as the oil and gas industry or feedwater systems in nuclear
Guilherme Siqueira de Aquino +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Frontiers in Marine ScienceThis study explores the impact of sub-mesoscale structures and vertical advection on the connectivity properties of the Baltic Sea using a Lagrangian approach. High-resolution flow fields from the General Estuarine Transport Model (GETM) were employed to
Saeed Hariri +2 more
doaj +1 more source