Results 191 to 200 of about 3,224,146 (301)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Outcomes of early oral antibiotic transition for the treatment of uncomplicated enterococcal bacteremia. [PDF]

Antimicrob Steward Healthc Epidemiol
Li C, Schultze M, Tedeschi C, Rock A, Gillett E, Letourneau A, Wu T.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stage-dependent role of NEK7 in the inactive-to-active conformational transition of NLRP3 monomer. [PDF]

PLoS Comput Biol
Peng J, Li W, Wang H, Chen X, Zhang M, Sun B.   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Probing and controlling coherent and incoherent dynamics of phase transitions via multipulse excitation. [PDF]

Sci Adv
Guo FW, Liu WH, Wang Z, Wei ZM, Li SS, Wang LW, Luo JW.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Transition to organic production

The purpose of this database is to provide organic farmers and agronomists access to resources containing information on successful ways to transition to organic production.
Transition to organic production, Organic Agriculture Centre of Canada
core  

Strong exciton coupling: a practical toolbox for computing interaction energies, wavefunctions, and optical spectra.

Chem Soc Rev
Ringström R, Hashemi SR, Liang Y, Hestand NJ, Börjesson K.   +4 more
europepmc   +1 more source

Velocity gauge for oscillator strength in ΔSCF theory. [PDF]

J Chem Phys
Shen Y, Fan Y, Yang W.
europepmc   +1 more source